Volume 21, Issue 3 (6-2018)
J Arak Uni Med Sci 2018, 21(3): 33-41 |
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Jalalvand F, Asle-Rousta M. Effect of Myrtus Communis Hydro-Alcoholic Extract on Chronic Restraint Stress-Induced Spatial Memory Deficit in Adult Male Rats. J Arak Uni Med Sci 2018; 21 (3) :33-41
URL: http://jams.arakmu.ac.ir/article-1-5517-en.html
URL: http://jams.arakmu.ac.ir/article-1-5517-en.html
1- Department of Biology, Malard Branch, Islamic Azad University, Malard, Iran. , biology1358@gmail.com
2- Department of Animal Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran.
2- Department of Animal Physiology, Zanjan Branch, Islamic Azad University, Zanjan, Iran.
Abstract: (2236 Views)
Background and Aim: Chronic restraint stress impairs spatial learning and memory. Myrtle (Myrtus communis) has antioxidant, antidiabetic, hepatoprotective and neuroprotective properties. The aim of this study was to investigate the effect of myrtle hydroalcoholic extract on chronic restraint stress-induced spatial learning and memory deficit in adult male Wistar rats.
Materials and Methods: In this experimental study, 80 adult male Wistar rats were allocated to eight groups (10 in each) included control group (intact), myrtle0.75, myrtle1.5, myrtle3 groups (were gavaged with hydroalcoholic extract of myrtle at 0.75, 1.5 and 3 mg/ kg bw doses), stress group (restrained in restrainers for 6 hours per day for 21 consecutive days), stress- myrtle0.75, stress-myrtle1.5 and stress- myrtle3 groups (received myrtle extract at 0.75, 1.5 and 3 mg/ kg bw doses and exposed to chronic immobility stress). Spatial learning and memory were examined through the Morris water maze test.
Findings: Chronic immobilization stress caused spatial learning and memory impairment. Consuming doses 1.5 and 3 of Myrtle extract to stressed animals caused significant decrease in spent time and swam distance to reach the hidden platform (p<0.05) and increased time lapsed in target quadrant comparing with stress group (p<0.05).
Conclusion: It has been concluded that myrtle extract can improve spatial learning and memory in rats exposed to stress in a dose dependent manner.
Materials and Methods: In this experimental study, 80 adult male Wistar rats were allocated to eight groups (10 in each) included control group (intact), myrtle0.75, myrtle1.5, myrtle3 groups (were gavaged with hydroalcoholic extract of myrtle at 0.75, 1.5 and 3 mg/ kg bw doses), stress group (restrained in restrainers for 6 hours per day for 21 consecutive days), stress- myrtle0.75, stress-myrtle1.5 and stress- myrtle3 groups (received myrtle extract at 0.75, 1.5 and 3 mg/ kg bw doses and exposed to chronic immobility stress). Spatial learning and memory were examined through the Morris water maze test.
Findings: Chronic immobilization stress caused spatial learning and memory impairment. Consuming doses 1.5 and 3 of Myrtle extract to stressed animals caused significant decrease in spent time and swam distance to reach the hidden platform (p<0.05) and increased time lapsed in target quadrant comparing with stress group (p<0.05).
Conclusion: It has been concluded that myrtle extract can improve spatial learning and memory in rats exposed to stress in a dose dependent manner.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2017/12/17 | Accepted: 2018/04/11
Received: 2017/12/17 | Accepted: 2018/04/11
References
1. McEwen BS. Neurobiological and systemic effects of chronic stress. Chronic Stress. 2017; 1: 1-11.
2. Huang RR, Hu W, Yin YY, Wang YC, Li WP, Li WZ. Chronic restraint stress promotes learning and memory impairment due to enhanced neuronal endoplasmic reticulum stress in the frontal cortex and hippocampus in male mice. International journal of molecular medicine. 2015; 35(2):553-9.
3. Fontella FU, Siqueira IR, Vasconcellos AP, Tabajara AS, Netto CA, Dalmaz C. Repeated restraint stress induces oxidative damage in rat hippocampus. Neurochemical research. 2005; 30(1):105-11.
4. Jangra A, Sriram CS, Dwivedi S, Gurjar SS, Hussain MI, Borah P, Lahkar M. Sodium phenylbutyrate and edaravone abrogate chronic restraint stress-induced behavioral deficits: implication of oxido-nitrosative, endoplasmic reticulum stress cascade, and neuroinflammation. Cellular and molecular neurobiology. 2017; 37(1):65-81.
5. Zhang Y, Liu W, Zhou Y, Ma C, Li S, Cong B. Endoplasmic reticulum stress is involved in restraint stress-induced hippocampal apoptosis and cognitive impairments in rats. Physiology & behavior. 2014; 131:41-8.
6. Alfarez DN, Joëls M, Krugers HJ. Chronic unpredictable stress impairs long‐term potentiation in rat hippocampal CA1 area and dentate gyrus in vitro. European Journal of Neuroscience. 2003; 17(9):1928-34.
7. Ghadrdoost B, Vafaei AA, Rashidy-Pour A, Hajisoltani R, Bandegi AR, Motamedi F, Haghighi S, Sameni HR, Pahlvan S. Protective effects of saffron extract and its active constituent crocin against oxidative stress and spatial learning and memory deficits induced by chronic stress in rats. European journal of pharmacology. 2011; 667(1):222-9.
8. Romani A, Coinu R, Carta S, Pinelli P, Galardi C, Vincieri FF, Franconi F. Evaluation of antioxidant effect of different extracts of Myrtus communis L. Free radical research. 2004; 38(1):97-103.
9. Alipour G, Dashti S, Hosseinzadeh H. Review of pharmacological effects of Myrtus communis L. and its active constituents. Phytotherapy research. 2014; 28(8):1125-36.
10. Baharvand-Ahmadi B, Bahmani M, Naghdi N, Saki K, Baharvand-Ahmadi S, Rafieian-Kopaei M. Review on phytochemistry, therapeutic and pharmacological effects of myrtus (Myrtus communis). Der Pharmacia Lettre. 2015; 7(11):160-5.
11. Asgarpanah J, Ariamanesh A. Phytochemistry and pharmacological properties of Myrtus communis L. indian journal of traditional knowledge. 2015; 1(1): 82-87.
12. Kumar R, Phaneendra P, Bodhanapu S, Rahiman F, Niay M, Tamizmani T, Antioxidant and hepatoprotective activity of the aqueous extract of Myrtus communis (myrtle) leaves, Pharmacololgy. 2011; 1: 1083-1090.
13. Ranjan N, Kumari M. Acetylcholinesterase inhibition by medicinal plants: A Review. Annals of Plant Sciences. 2017; 6(06):1640-4.
14. Johari H, Nozari M, Moghtari M, Zamani Z, Yazdani M. The effect of myrtus communis extract on liver enzymes and blood biochemical factors in diabetic adult male rats. Zahedan Journal of Research in Medical Sciences. 2014; 16(10):12-7.
15. MacDowell KS, Caso JR, Martín-Hernández D, Madrigal JL, Leza JC, García-Bueno B. Paliperidone prevents brain Toll-like receptor 4 pathway activation and neuroinflammation in rat models of acute and chronic restraint stress. International Journal of Neuropsychopharmacology. 2015; 18(3): pyu070.
16. Asle-Rousta M, Oryan S, Ahmadiani A, Rahnema M. Activation of sphingosine 1-phosphate receptor-1 by SEw2871 improves cognitive function in Alzheimer's disease model rats. EXCLI J. 2013; 12: 449-461.
17. Tumen I, Senol FS, Orhan IE. Inhibitory potential of the leaves and berries of Myrtus communis L.(myrtle) against enzymes linked to neurodegenerative diseases and their antioxidant actions. International journal of food sciences and nutrition. 2012; 63(4):387-92.
18. Choudhary MI, Khan N, Ahmad M, Yousuf S, Fun HK, Soomro S, Asif M, Mesaik MA, Shaheen F. New inhibitors of ROS generation and T-cell proliferation from Myrtus communis. Organic letters. 2013; 15(8):1862-5.
19. Xu P, Wang K, Lu C, Dong L, Gao L, Yan M, Aibai S, Yang Y, Liu X. Protective effects of linalool against amyloid beta-induced cognitive deficits and damages in mice. Life Sciences. 2017; 174:21-7.
20. Moss M, Oliver L. Plasma 1, 8-cineole correlates with cognitive performance following exposure to rosemary essential oil aroma. Therapeutic advances in psychopharmacology. 2012; 2(3):103-13.
21. Lee GY, Lee C, Park GH, Jang JH. Amelioration of Scopolamine-Induced Learning and Memory Impairment by α-Pinene in C57BL/6 Mice. Evidence-Based Complementary and Alternative Medicine. 2017(2017): 1-9.
22. Spencer JP. The impact of flavonoids on memory: physiological and molecular considerations. Chemical Society Reviews. 2009; 38(4): 1152-1161.
23. Hämäläinen, M., Nieminen, R., Vuorela, P., Heinonen, M. and Moilanen, E. Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages. Mediators of inflammation, 2007:1-10.
24. Ghanei Nasab S, Hadizadeh F, Marjani A. Effects of Different Coumarin-3-Carboxamide Agents on Scopolamine Induced Learning and Memory Deficit in Mice. Elderly Health Journal. 2017; 3(1):50-4.
25. Hornick A, Lieb A, Vo NP, Rollinger J, Stuppner H, Prast H. Effects of the coumarin scopoletin on learning and memory, on release of acetylcholine from brain synaptosomes and on long-term potentiation in hippocampus. InBMC Pharmacology 2008; 8 (S1) A36.
26. Anwar J, Spanevello RM, Thomé G, Stefanello N, Schmatz R, Gutierres J, Vieira J, Baldissarelli J, Carvalho FB, da Rosa MM, Rubin MA. Effects of caffeic acid on behavioral parameters and on the activity of acetylcholinesterase in different tissues from adult rats. Pharmacology Biochemistry and Behavior. 2012; 103(2):386-94.
27. Fernandes FD, Menezes AP, de Sousa Neves JC, Fonteles AA, da Silva AT, de Araújo Rodrigues P, do Carmo MR, de Souza CM, de Andrade GM. Caffeic acid protects mice from memory deficits induced by focal cerebral ischemia. Behavioural pharmacology. 2014; 25(7):637-47.
28. Mansouri MT, Naghizadeh B, Ghorbanzadeh B, Farbood Y, Sarkaki A, Bavarsad K. Gallic acid prevents memory deficits and oxidative stress induced by intracerebroventricular injection of streptozotocin in rats. Pharmacology Biochemistry and Behavior. 2013; 111:90-6.
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