Volume 21, Issue 5 (10-2018)
J Arak Uni Med Sci 2018, 21(5): 32-41 |
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Jamilian M, Ravanbakhsh N. Effects of Vitamin E plus Omega-3 Supplementation on Inflammatory Factors, Oxidative Stress Biomarkers and Pregnancy Consequences in Women with Gestational Diabetes. J Arak Uni Med Sci 2018; 21 (5) :32-41
URL: http://jams.arakmu.ac.ir/article-1-5638-en.html
URL: http://jams.arakmu.ac.ir/article-1-5638-en.html
1- Department of Gynecology, Arak University of Medical Sciences, Arak, Iran.
2- Department of Gynecology, Arak University of Medical Sciences, Arak, Iran. , ravanbakhsh.nazanin@gmail.com
2- Department of Gynecology, Arak University of Medical Sciences, Arak, Iran. , ravanbakhsh.nazanin@gmail.com
Abstract: (16887 Views)
Background and Aim: We are aware of no study that examined the effects of vitamin E plus omega-3 fatty acid supplementation on inflammatory and oxidative stress biomarkers in pregnant women with gestational diabetes (GDM). This study aimed to evaluate the effects of vitamin E plus omega-3 supplementation on insulin metabolism and inflammatory and oxidative stress biomarkers in pregnant women with gestational diabetes.
Materials and Methods: This randomized, double-blind, placebo-controlled clinical trial was performed on 60 women with GDM. Subjects were randomly assigned to receive either 400 IU vitamin E plus 1000 mg omega-3 fatty acid supplements (n=30) or placebo (n=30) for 6 weeks. Fasting blood samples were taken at study baseline and after 6 weeks of intervention to quantify biochemical variables.
Findings: Vitamin E plus omega-3 fatty acid supplementation led to a significant rise in plasma total antioxidant capacity (+187.5±224.9 vs. -32.5±136.1 mmol/L, p<0.001) and a significant decrease in MDA levels (-0.1±0.9 vs. +0.6±1.4 µmol/L, p=0.04) compared with placebo. Furthermore, a significant increase in plasma NO levels (+5.0±7.7 vs. -12.0±28.0 µmol/L, p=0.002) was seen after vitamin E plus omega-3 fatty acid supplementation compared with the placebo.
Conclusion: Vitamin E plus omega-3 fatty acid supplementation in GDM women had beneficial effects on biomarkers of inflammation and oxidative stress.
Materials and Methods: This randomized, double-blind, placebo-controlled clinical trial was performed on 60 women with GDM. Subjects were randomly assigned to receive either 400 IU vitamin E plus 1000 mg omega-3 fatty acid supplements (n=30) or placebo (n=30) for 6 weeks. Fasting blood samples were taken at study baseline and after 6 weeks of intervention to quantify biochemical variables.
Findings: Vitamin E plus omega-3 fatty acid supplementation led to a significant rise in plasma total antioxidant capacity (+187.5±224.9 vs. -32.5±136.1 mmol/L, p<0.001) and a significant decrease in MDA levels (-0.1±0.9 vs. +0.6±1.4 µmol/L, p=0.04) compared with placebo. Furthermore, a significant increase in plasma NO levels (+5.0±7.7 vs. -12.0±28.0 µmol/L, p=0.002) was seen after vitamin E plus omega-3 fatty acid supplementation compared with the placebo.
Conclusion: Vitamin E plus omega-3 fatty acid supplementation in GDM women had beneficial effects on biomarkers of inflammation and oxidative stress.
Type of Study: Original Atricle |
Subject:
Obstetrics & Gynocology
Received: 2018/02/21 | Accepted: 2018/05/29
Received: 2018/02/21 | Accepted: 2018/05/29
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