Volume 22, Issue 1 (4-2019)                   J Arak Uni Med Sci 2019, 22(1): 1-14 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Bahreloloum Tabatabai M, Mirjalili M, Yazdiyan F, Hekmatimoghaddam S. Design and Production of A Wound Cover Containing Essence of Ajwain (Trachyspermum) by Nanoliposome Technique, and Assessment of Its Physical, Chemical, Antibacterial and Cytotoxicity Properties . J Arak Uni Med Sci. 2019; 22 (1) :1-14
URL: http://jams.arakmu.ac.ir/article-1-5787-en.html
1- Department of Textile and Polymer Engineering, Faculty of Textile and Polymer, Yazd Branch, Islamic Azad University, Yazd, Iran.
2- Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran.
3- Department of Laboratory Sciences, School of Paramedicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. , hekmati@ssu.ac.ir
Abstract:   (437 Views)
Background and Aim: The aim of this study was to assess the applied characteristics of wound covers containing nanoliposomic essential oil of ajwain, with suitable antimicrobial properties and lack of cytotoxicity.
Materials and Methods: Liposomal formulations of the ajwain essential oil containing DSPE-PEG, cholesterol, span60 and SPC80 were prepared using a thin layer method. The rooting and spray methods on a cellulose fabric were used to produce skin wound cover. In addition to in vitro intracellular penetration and measurement of minimum inhibitory concentration of the product, textile characteristics, antimicrobial activity and 96 hours release of the essence in the wound cover were studied.
Ethical Considerations: In this study, all principles of research ethics were considered.
Findings: The loading efficiency of the liposomal formulation was more than 85%. The small particle dispersion index (PDI = 0.02) in the form of the PEGylated formulation indicates optimal dispersion of the particles which reduces the buildup of the drug in the cutaneous application. The standard AATCC microbial test showed inhibitory effect of the wound cover on bacteria, especially E. coli. Textile tests indicated acceptable properties of the produced wound cover, too.
Conclusion: Altogether, this wound cover showed acceptable features in combating the two selected bacteria responsible for infectious skin ulcers.
Full-Text [PDF 857 kb]   (176 Downloads)    
Type of Study: Original Atricle | Subject: Infection
Received: 2018/05/20 | Accepted: 2018/09/2

1. Geerligs M, Oomens C, Ackermans P, Baaijens F, Peters G. Linear shear response of the upper skin layers. Biorheology. 2011; 48(3–4):229–45.
2. Boateng JS, Matthews KH, Stevens HNE, Eccleston GM. Wound healing dressings and drug delivery systems: a review. J. Pharm. Sci. 2008; 97(8):2892–923.
3. Amoabediny G, Haghiralsadat F, Naderinezhad S, Helder MN, Akhoundi Kharanaghi E, Mohammadnejad Arough J, et al. Overview of preparation methods of polymeric and lipid-based (noisome, solid lipid, liposome) nanoparticles: A comprehensive review. Int. J. Polym. Mater.Polym. Biomater. 2017; 1–18.
4. Goldberg M, Langer R, Jia X. Nanostructured materials for applications in drug delivery and tissue engineering. J. Biomater. Sci., Polym. Ed. 2007; 18(3):241–68.
5. Zhang H-Y, Liang F, Zhang J-W, Wang F, Wang L, Kang X-G. Effects of long noncoding RNA-ROR on tamoxifen resistance of breast cancer cells by regulating microRNA-205. Cancer Chemother. Pharmacol. 2017; 79(2):327–37.
6. Larson ML, Rubenstein SE, Schiller GJ, Solomon SR, Louie AC, Paulsen KH, et al. Study design of an expanded access protocol of cpx-351 (cytarabine: daunorubicin) liposome injection in patients 60-75 years of age with secondary acute myeloid leukemia. Biol. Blood Marrow Transplant. 2017; 23(3):S249–50.
7. Xu H, Zhang L, Li L, Liu Y, Chao Y, Liu X, et al. Membrane-loaded doxorubicin liposomes based on ion-pairing technology with high drug loading and ph-responsive property. AAPS PharmSciTech. 2017; 18(6):2120–30.
8. Seibel NL, Shad AT, Bekersky I, Groll AH, Gonzalez C, Wood L V, et al. Safety, tolerability, and pharmacokinetics of liposomal amphotericin B in immunocompromised pediatric patients. Antimicrob. Agents Chemother. 2017; 61(2):e01477-16.
9. Edwards JV, Vigo TL. Bioactive fibers and polymers. ACS Publications; 2001.
10. Dastjerdi R, Montazer M. A review on the application of inorganic nano-structured materials in the modification of textiles: focus on anti-microbial properties. Colloids Surf., B. 2010; 79(1):5–18.
11. Becker MA, Willman P, Tuross NC. The US first ladies gowns: a biochemical study of silk preservation. J. Am. Inst. Conserv. 1995; 34(2):141–52.
12. Forlani G, Seves AM, Ciferri O. A bacterial extracellular proteinase degrading silk fibroin. Int. Biodeterior. Biodegrad. 2000; 46(4):271–5.
13. Kumar VS, Nagaraja BM, Shashikala V, Padmasri AH, Madhavendra SS, Raju BD, et al. Highly efficient Ag/C catalyst prepared by electro-chemical deposition method in controlling microorganisms in water. J. Mol. Catal. A: Chem. 2004; 223(1):313–9.
14. Tang Z, Liu S, Dong S, Wang E. Electrochemical synthesis of Ag nanoparticles on functional carbon surfaces. J. Electroanal. Chem. 2001; 502(1):146–51.
15. Pradhan N, Pal A, Pal T. Silver nanoparticle catalyzed reduction of aromatic nitro compounds. Colloids Surf., A. 2002; 196(2):247–57.
16. Sweeney IR, Miraftab M, Collyer G. A critical review of modern and emerging absorbent dressings used to treat exuding wounds. Int. Wound. J. 2012; 9(6):601–12.
17. Stashak TS, Farstvedt E, Othic A. Update on wound dressings: indications and best use. Clin.Tech. Equine Pract. 2004; 3(2):148–63.
18. Fan Z, Liu B, Wang J, Zhang S, Lin Q, Gong P, et al. A novel wound dressing based on Ag/graphene polymer hydrogel: effectively kill bacteria and accelerate wound healing. Adv. Funct. Mater. 2014; 24(25):3933–43.
19. Celia C, Trapasso E, Locatelli M, Navarra M, Ventura CA, Wolfram J, et al. Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids Surf., B. 2013; 112:548–53.
20. Benita S. Microencapsulation: methods and industrial applications. CRC Press; 2005.
21. Nelson G. Microencapsulation in textile finishing. Color. Technol. 2001; 31(1):57–64.
22. Pandooneh A, Zuhair MH, Taghi A. The effect of molecule isolated from garlic on the survival of the transplanted alogenic intestine in Balb/c mice. Kowsar. 1996; 2:119–27.
23. Roberto CH. medicinal plants photo dictionary. Traditional Medicine & Material Medical Research Center Tehran University of Medical Sciences. 2005; (Persian).
24. Balbba SI, Hilal SH, Hoggag MR. Active constituents of Ammi majus fruit at different stages. Acta Med. 1973; 23(4):372–80.
25. Mood BS, Shafeghat M, Metanat M, Saeidi S, Sepehri N. The inhibitory effect of ajowan essential oil on bacterial growth. International Journal of Infection. 2014; 1(2).
26. Burt S. Essential oils: their antibacterial properties and potential applications in foods—a review. Int. J. Food Microbiol. 2004; 94(3):223–53.
27. Mahboubi M, Kazempour N. Chemical composition and antimicrobial activity of Satureja hortensis and Trachyspermum copticum essential oil. Int. J. Mic. 2011; 3(4):194.
28. Haghiralsadat F, Azhdari M, Kalantar SM, Naderinezhad S, Teymourizadeh K, Yazdani M, et al. Strategy of Improvements in the rapeutic index of medicinal herbs of Iranianin digenous: Synthesis and characterization of phospholipid lipid-based vesicles in corporated Trachyspermum copticum. SSU_Journals. 2016; 24(6):468–78.

Add your comments about this article : Your username or Email:

Send email to the article author

© 2019 All Rights Reserved | Journal of Arak University of Medical Sciences

Designed & Developed by : Yektaweb