Volume 22, Issue 5 (11-2019)                   J Arak Uni Med Sci 2019, 22(5): 18-31 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hajihashemi S, Rajabi R, Ghiasabadi Farahani A. The Oral Post-Treatment Effect of Hydroethanolic Extract of Origanum Vulgare on Acute Kidney Injury Caused by Gentamicin in Rats. J Arak Uni Med Sci 2019; 22 (5) :18-31
URL: http://jams.arakmu.ac.ir/article-1-6131-en.html
1- Department of Physiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran. , s.hajihashemi@gmail.com
2- Department of Physiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Abstract:   (2233 Views)
Background and Aim Gentamicin antibiotic has some side effects such as nephrotoxicity. The aim of this study was to evaluate the post-treatment effects of using hydroethanolic extract of Origanum Vulgare (OV) on nephrotoxicity caused by gentamicin.
Methods & Materials In this study, 32 male Wistar rats were divided into four groups of control (n=8), gentamicin (n=8; 100 mg/kg/day intraperitoneally for 8 days and gavage of distilled water for 2 days), OV extract group (intraperitoneal injection of normal saline for 8 days and using 40 mg/kg OV extract by gavage for 2 days), and gentamicin+ OV extract (intraperitoneal injection of gentamicin 100 mg/kg/day for 8 days and using 40 mg/kg OV extract by gavage for 2 days). The concentration of urea, creatinine, sodium, potassium and osmolarity were measured in plasma and urine samples. The right kidney was used to measure Malondialdehyde (MDA) and Ferric Reducing Antioxidant Power (FRAP).
Ethical Considerations This article was obtained from a research proposal approved by the Research Ethics Committee of Arak University of Medical Sciences (Code:IR.ARAKMU.REC. 1394.284)
Results Post-treatment administration of hydroethanolic extract of OV significantly decreased the concentration of urea, creatinine, absolute sodium excretion, relative sodium and potassium excretion, and MDA levels but significantly increased creatinine, urine osmolality and FRAP levels. 
Conclusion Oral administration of OV extract as post-treatment method improved nephrotoxicity caused by gentamicin use by reducing oxidative stress of oxygen free radicals and lipid peroxidation in the affected kidneys. 
Full-Text [PDF 6536 kb]   (1082 Downloads) |   |   Full-Text (HTML)  (2173 Views)  
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2019/08/14 | Accepted: 2019/09/7

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Arak University of Medical Sciences

Designed & Developed by : Yektaweb