Volume 2, Issue 7 (Summer 1999)
J Arak Uni Med Sci 1999, 2(7): 10-17 |
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Sadeghi A, Mozdarani H. The Study of Protective Effect of Cimetidine Against Genetical Effects Due to Benzene with Micronuclei Assay. J Arak Uni Med Sci 1999; 2 (7) :10-17
URL: http://jams.arakmu.ac.ir/article-1-6581-en.html
URL: http://jams.arakmu.ac.ir/article-1-6581-en.html
1- School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Abstract: (752 Views)
This research is performed to assess clastogenic capacity of cimetidine(CT) against clastogenic effect induced by benzene in terms of micronuclei. For this purpose micronuclei assay method was used. In each experimental group m 5 Balb /C mices was used. 24 hours after i. p .injections slides was prepared from bone marrow and frequency of micronuclei in polychromatic erythrocytes (PCEs) and normochromatic erythrocytes (NCEs) was obtained. Results indicated that CT at therapeutic dose (20mg/kg. b. w) can be reduce genetical damages (micronuclei) due to benzene (1010mg/Kb. B. w) with a dose- related manner (p<0.01, = -0.82). Therefore , our results indicated that CT has anticlastogenic capacity. According to above results and relatively long term use of CT, we suggest using it in the cases in which someone exposed to clastogenic agents such as benzene, especially when someone also suffer from diseases such as peptic ulcer.
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