Volume 2, Issue 9 (Winter 1999)
J Arak Uni Med Sci 1999, 2(9): 43-48 |
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Mohajerani H. The Importance of Knowing the Sodium- Potassium Pump Physiology in Recent Improvements of Heart Failure Treatment. J Arak Uni Med Sci 1999; 2 (9) :43-48
URL: http://jams.arakmu.ac.ir/article-1-6603-en.html
URL: http://jams.arakmu.ac.ir/article-1-6603-en.html
School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Abstract: (4489 Views)
Sodium, potassium pump is a plasma membrane enzyme. It is almost in all of the animal cells. Because of this ubiquitous distribution and situation of this pump as a digitalis receptor, cardiac glycosides can effect not only myocardial function, but also many of the cell processes in other tissues. This matter evoke the question of how cardiac glycosides have selective function without disturbance of function of the other body cells? A part of the answer of this question is relate to diversity of digitalis receptor in molecular level . Therefore a clear definition of relative selectivity of the cardiac glycosides is the presence of difference isoforms of sodium pump with low affinity. If the drug dose increases, side effects will appear. Therefore the final aim might be the design of drugs that only affect on isoform of the heart.
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