Volume 3, Issue 2 (Summer 2000)
J Arak Uni Med Sci 2000, 3(2): 32-34 |
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Fani A. Introduction of 6 Patients With Pheochromocytoma in an 11 Person Family. J Arak Uni Med Sci 2000; 3 (2) :32-34
URL: http://jams.arakmu.ac.ir/article-1-6620-en.html
URL: http://jams.arakmu.ac.ir/article-1-6620-en.html
School of Medicine, Arak University of Medical Sciences, Arak, Iran.
Abstract: (1405 Views)
A brief history and the result: Mr V.M> who died at age of 63 because of cardiac attack and his wife doesn’t mention any symptoms of pheo such az hypertension , catecholamine release and so on. From the 7 girls, one died at age of 18 because of hypertension crisis and CVA. The second girl died during bilateral adrenalectomy .Three of them had extension to inferior vena cava. One boy died at age of 12 with clinical signs and symptoms of pheo. The second boy at age of 27 was healthy with no sign and symptom. All of the family were checked for MEN2 and no one had positive finding. On the basis of history, clinical and paraclinical results, it seems that they have familiar bilateral autosomal dominant pheo with high peneterance. The 24hrs urine collection for measuring VMA and free catecholamines was recommended for each patient. Two positive results of three tests are highly sensitive and suggestive to pheo diagnosis. We can use MIBG.1131, tolemerase En.s which is only secreted by tumoral cell as a specific tool for evalution of malignancy. Although pheo is considered as 0.1% of etiology of hypertension, it is a curable cause. Any young patient with labile hypertension, anxiety, palpitation, seating, weight loss must be considered and worked up for pheo.
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