Volume 4, Issue 2 (Summer 2001)                   J Arak Uni Med Sci 2001, 4(2): 1-6 | Back to browse issues page

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Rastegar Lari A, Shamshiri A, Masgedian F, Salek Moghaddam A. ‍Comparative In-Vitro Activity of Ofloxacin vs Ceftriaxone Against Gram Negative From Patients With Urinary Tract Infection. J Arak Uni Med Sci 2001; 4 (2) :1-6
URL: http://jams.arakmu.ac.ir/article-1-6653-en.html
1- Faculty of Medicine, Iran University of Medical Sciences, Iran, Tehran.
2- General Practitionar, Iran University of Medical Sciences, Iran, Tehran.
3- Faculty of Medicine, Iran University of Medical Sciences, Iran, Tehran.
Abstract:   (1565 Views)
The present study was carried out to evaluate the in-vitro susceptibility of isolated gram-negative bacteria from hospitalized patients  with  urinary  tract  infection (UTI)  to  ofloxacin  in  comparison  with  ceftriaxone  and  other  conventional  antibiotics. Gram-negative  rods  (408  samples)  isolated  from  hospitalized  patients  with  UTI  from  September  1998  to  Janury  1999  and  their  sensitivity  to  various  antibiotics  were  determined. Minimum  Inhibitory  Concentration  (9MIC)  of ofloxacin and ceftriaxone were evaluated according to National Committee for Clinical Laboratoty  Standard (NCCLS)  recommendations. The  predominant  organisms  were Escherichia  coli (68.3%), Pseudomonas  spp (15.4%), Enterobacter  spp (6.7%), Proteus  spp (6.2%) and Klebsiella (3.4%). The percentage of resistance  for  all  strains  was  86.8%, 51.6%, 27%  for  ampicillin, trimethoprim-sulfamethoazazole and  nalidixic  acid respectively, 24.8%  for nitrofurantoine, 27.2%  for gentamicin, 13.6%  for  ofloxacin  and  14%  for  ceftriaxocine.  Enterobacteriacea  was  more  sensitive to ofloxacin (99%), but  Pseudomonas  spp, were  weakly  sensitive  to  ofloxacin (60%), Also  in  the  case  of  ceftriaxone, enterobacteriaxea  was  the most sensitive bacteria (90%) and sensitivity  of  E.coli  and  pseudomonas  spp. To  ceftriaxone  were  86.5%  and  70%  respectively. In our study there was no significant difference between ofloxacin and ceftriaxone (P=0.88).  Both antibiotics had in-vitro broad activity against gram-negative bacteria in hospitalized patients with UTI.  Larger-scale studies are  recommended to compare the effect of oral ofloxacin with parental ceftriaxone in patients.
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Type of Study: Original Atricle | Subject: Infection
Accepted: 2001/06/22

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