Volume 4, Issue 4 (Winter 2001)
J Arak Uni Med Sci 2001, 4(4): 8-14 |
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Yadollahi M, Saadat M, Omidvari S, Saadat I. Genetic Polymorphism GSTMI by PCR and Susceptibility to Stomach Cancer. J Arak Uni Med Sci 2001; 4 (4) :8-14
URL: http://jams.arakmu.ac.ir/article-1-6676-en.html
URL: http://jams.arakmu.ac.ir/article-1-6676-en.html
1- Khatam University.
2- Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
3- Department of Chemotrophy, College of Sciences, Shiraz University, Shiraz, Iran.
2- Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
3- Department of Chemotrophy, College of Sciences, Shiraz University, Shiraz, Iran.
Abstract: (1302 Views)
Introduction: Glutatathion s-transferases (GST) are enzyme encoded by a multigene family and have important roles in detoxification of some strong carcinogens. Human GSTs are categorized into four groups. Namely π، μ، α، θ GSTM! Is a member of GST m previous studies revealed that absence of GSTM1 protein associates with increased risk of development of several malignancies.
Material and Method: In the current study, the relationship between GSTM1 genetic polymorphism and the susceptibility for being involved by gastric carcinoma was explored. Forthy patients with gastric carcinoma and 80 normal individuals (control group) were studied. GSTM1 genetic polymorphism between exons 5 and 6 was explored using a PCR technique. For each patient a questionair including gender, age, cigarette smoking, habit, and history of neoplasia in first-degree relatives was completed.
Results: The relative frequencies of null genotype in the control group and gastric cancer were 31.25 and 60% respectively. There was a statistically significant (x2=9.21; p<0.05) assessment between GSTM! Null genotype and development of gastric carcinoma.
Conclusion: Not mentioning the GSTM1 genotype, cigarette smoking and a positive family history had significant correlations with development of stomach malignancy.
Material and Method: In the current study, the relationship between GSTM1 genetic polymorphism and the susceptibility for being involved by gastric carcinoma was explored. Forthy patients with gastric carcinoma and 80 normal individuals (control group) were studied. GSTM1 genetic polymorphism between exons 5 and 6 was explored using a PCR technique. For each patient a questionair including gender, age, cigarette smoking, habit, and history of neoplasia in first-degree relatives was completed.
Results: The relative frequencies of null genotype in the control group and gastric cancer were 31.25 and 60% respectively. There was a statistically significant (x2=9.21; p<0.05) assessment between GSTM! Null genotype and development of gastric carcinoma.
Conclusion: Not mentioning the GSTM1 genotype, cigarette smoking and a positive family history had significant correlations with development of stomach malignancy.
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