Volume 7, Issue 2 (Summer 2004)
J Arak Uni Med Sci 2004, 7(2): 39-47 |
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Mohammad Alizadeh A H, Maghoolzadeh A R. Comparison of Thyme Combination Regimen With Routine Regimen for Eradication of Helicobacter Pylori (HP) in Peptic Ulcer Patients. J Arak Uni Med Sci 2004; 7 (2) :39-47
URL: http://jams.arakmu.ac.ir/article-1-6785-en.html
URL: http://jams.arakmu.ac.ir/article-1-6785-en.html
Abstract: (4981 Views)
Introduction: Hp is the most common human infection which can result in gastritis, peptic ulcer and gastric adenocarcinoma and lymphoma. Several combinations of drugs have been tested in HP eradication. Thyme is a herbal drug that has antiseptic and GI anti spasmodic characteristics. In this study we tested Thyme combination regimen in comparison with routine regimes.
Materials and Methods: This is a randomized clinical trial study. 90 patients with GI symptoms, confirmed peptic ulcer and HP infections, were divided into three groups, group A (Omeperazole, Bismuth, Metronidazole and Tetracycline), group B: Omeperazole, Bismuth, Metronidazole, Tetracycline and Thyme and group C: Bismuth, Omeperazole, Tetracycline and Thyme. Duration of treatment was 2 weeks . after treatment they were given Ranitidine for 2 weeks and 2 weeks without any treatment and then they were evaluated for HP and peptic ulcer.
Results: Distribution of sex, age, and smoking was equal in three groups, 81 (90%) of cases had upper epigastric pain. Clinical recovery rate was 96.6% in group B and C which was more than group A (p=0.43). After treatment endoscopy showed 70% complete relief in group C which was significantly more than two other groups (p=0.04). Complete response rate (negative RUT+ negative HP histology) was 46.7% in group C (p=0.03).
Conclusion: In general, group C regimen that substituted Thyme with Metronidazol was more effective in HP eradication. With regard to high effectiveness, low complication and low cost of Thyme, we suggest that adding this drug to routine quadriple HP eradication regimens could be useful.
Materials and Methods: This is a randomized clinical trial study. 90 patients with GI symptoms, confirmed peptic ulcer and HP infections, were divided into three groups, group A (Omeperazole, Bismuth, Metronidazole and Tetracycline), group B: Omeperazole, Bismuth, Metronidazole, Tetracycline and Thyme and group C: Bismuth, Omeperazole, Tetracycline and Thyme. Duration of treatment was 2 weeks . after treatment they were given Ranitidine for 2 weeks and 2 weeks without any treatment and then they were evaluated for HP and peptic ulcer.
Results: Distribution of sex, age, and smoking was equal in three groups, 81 (90%) of cases had upper epigastric pain. Clinical recovery rate was 96.6% in group B and C which was more than group A (p=0.43). After treatment endoscopy showed 70% complete relief in group C which was significantly more than two other groups (p=0.04). Complete response rate (negative RUT+ negative HP histology) was 46.7% in group C (p=0.03).
Conclusion: In general, group C regimen that substituted Thyme with Metronidazol was more effective in HP eradication. With regard to high effectiveness, low complication and low cost of Thyme, we suggest that adding this drug to routine quadriple HP eradication regimens could be useful.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2021/01/27 | Accepted: 2004/06/30
Received: 2021/01/27 | Accepted: 2004/06/30
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