Volume 7, Issue 2 (Summer 2004)
J Arak Uni Med Sci 2004, 7(2): 7-12 |
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Ranjbar A, Pasalar P, Abdollahi M, Delavar M. Oxidative Stress and Organophosphorous Status in Pesticide Manufacturing Workers. J Arak Uni Med Sci 2004; 7 (2) :7-12
URL: http://jams.arakmu.ac.ir/article-1-6789-en.html
URL: http://jams.arakmu.ac.ir/article-1-6789-en.html
Abstract: (1070 Views)
Introduction: Oxidative stress is one of the factors producing poisoning during chronic exposure to organophpsphporous poisons. In this research we studied oxidative stress status and acetycholinesterase in pesticide manufacturing workers.
Materials and Methods: This is a cross-sectional analytical study in which 45 organophopsphorous (OP) formulating pesticide workers with a minimum work history of 1 year in the age range of 23-35 were studied. Controls were age–matched workers of a food-making factory. They were evaluated for oxidative stress markers, including Tthiobarbituric acid-reactive substances (TBARS) indicator of lipid peroxidation (LPO), ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total Thiol (SH) groups and Gammaglutamyl transpeptidase (GGT) levels in blood and ACHE activity in erythrocytes.
Results: The results showed marked inhibition of ACHE, increased TBARS, decreased FRAP and decreased Thiol group level in workers. The reduction in activity of ACHE correlated well with increased TBARS and decreased FRAP in OP formualtors.
Conclusion: It is concluded that Op-formulating workers are exposed to more oxidative stress. The measurement of erythrocyte ACHE activity in pesticide workers who formulate Ops can be a good monitoring factor and is recommended to be performed in a regular manner.
Materials and Methods: This is a cross-sectional analytical study in which 45 organophopsphorous (OP) formulating pesticide workers with a minimum work history of 1 year in the age range of 23-35 were studied. Controls were age–matched workers of a food-making factory. They were evaluated for oxidative stress markers, including Tthiobarbituric acid-reactive substances (TBARS) indicator of lipid peroxidation (LPO), ferric reducing ability of plasma (FRAP) indicator of total antioxidant capacity, total Thiol (SH) groups and Gammaglutamyl transpeptidase (GGT) levels in blood and ACHE activity in erythrocytes.
Results: The results showed marked inhibition of ACHE, increased TBARS, decreased FRAP and decreased Thiol group level in workers. The reduction in activity of ACHE correlated well with increased TBARS and decreased FRAP in OP formualtors.
Conclusion: It is concluded that Op-formulating workers are exposed to more oxidative stress. The measurement of erythrocyte ACHE activity in pesticide workers who formulate Ops can be a good monitoring factor and is recommended to be performed in a regular manner.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2021/01/27 | Accepted: 2004/06/30
Received: 2021/01/27 | Accepted: 2004/06/30
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