Volume 24, Issue 5 (December & January 2021)                   J Arak Uni Med Sci 2021, 24(5): 634-639 | Back to browse issues page

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Samimi F, Azizi R, Jalali Mashayekhi F. Use of Nuclear Factor Erythroid 2-Eelated Factor Activators as A Strategy to Improve the Side Effects of COVID-19. J Arak Uni Med Sci 2021; 24 (5) :634-639
URL: http://jams.arakmu.ac.ir/article-1-6931-en.html
1- Department of Biochemistry and Genetics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
2- Department of Laboratory Sciences, Faculty of Medical Sciences, Khomein University of Medical Sciences, Khomein, Iran.
3- Department of Biochemistry and Genetics, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran. , mashayekhi@arakmu.ac.ir
Abstract:   (1233 Views)
Coronavirus disease-19 (COVID-19) is a new member of the coronavirus family causing acute respiratory infection. Patients with COVID-19 have a higher risk of developing oxidative stress during this infection. Moreover, the virus induces ROS production that activates cellular pathways for viral replication. 
Nuclear factor erythroid 2-related factor (Nrf2) is a crucial transcription factor in cellular antioxidant defense by mediating Virus-induced oxidative stress and ROS production. This article suggests that an Nrf2 activator may be beneficial in preventing oxidative stress development in COVID-19 patients. Coronaviruses are a significant group of viruses that cause different illnesses in humans and animals. These illnesses can range from the common cold to more severe diseases such as SARS (Severe acute respiratory syndrome), Middle East Respiratory Syndrome (MERS), and COVID-19. COVID-19 is a new viral disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 
The main symptoms of COVID-19-infected patients are fever, dry cough, fatigue, and sometimes respiratory problems such as shortness of breath, sore throat, and infection [1]. 
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Type of Study: Short Communication | Subject: Basic Sciences
Received: 2021/06/22 | Accepted: 2021/09/11

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