Volume 25, Issue 6 (February & March 2023)
J Arak Uni Med Sci 2023, 25(6): 41-49 |
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Molavi S, parastesh M, Saremi A, Bayatiyani M R. The Protective Effect of Resistance Training on Kidney Tissue and Changes in Serum Levels of Oxidant and Antioxidant Factors in Rats Exposed to X-ray Irradiation. J Arak Uni Med Sci 2023; 25 (6) :41-49
URL: http://jams.arakmu.ac.ir/article-1-7441-en.html
URL: http://jams.arakmu.ac.ir/article-1-7441-en.html
1- Department of Sport Physiology and Pathology, Faculty of Sport Sciences, Arak University, Arak, Iran
2- Department of of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran ,M-parastesh@Arak.ac.ir
3- Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran
4- Department of Radiotherapy and Medical Physics, Faculty of Para Medicine, Arak University of Medical Sciences and Khansari hospital, Arak, Iran
2- Department of of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran ,
3- Department of Sports Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran
4- Department of Radiotherapy and Medical Physics, Faculty of Para Medicine, Arak University of Medical Sciences and Khansari hospital, Arak, Iran
Abstract: (841 Views)
Introduction: In recent years, the use of X-rays in medicine and industry has expanded significantly. X-rays can cause oxidative stress and subsequently induce destructive effects on the kidneys. On the other hand, it has been proven that according to the theory of hormesis, resistance exercises have antioxidant effects, which may be used to reduce the harmful effects of X-rays. This study investigated the effect of resistance training on oxidative stress factors and structural changes in kidney tissue in rats exposed to X-rays
Methods: Twenty-four male rats were randomly divided into 4 groups. The irradiated groups were exposed to 4Gy X-ray. The training groups were exercised 5 times per week for 10 weeks. 24 hours after the last training session, blood samples were collected for evaluation of oxidative and antioxidant factors, and kidney tissue was isolated for stereological studies. The data was analyzed by one-way ANOVA in SPSS 20 software.
Results: In this study, whole-body X-ray irradiation caused a significant increase in kidney volume (P=0.003), cortex volume (P=0.02), glomerular volume (P=0.039), and serum Malondialdehyde (MDA) level (P=0.03). Also, performing the training protocol significantly reduced kidney volume (P=0.03), cortex volume (P=0.04), glomerular volume (P=0.033), and serum MDA level (P=0.02).
Conclusions: Based on this research, it seems that resistance training can lead to a decrease in glomerular filtration by creating adaptation and increasing antioxidant defense and changes in the hemodynamics of the kidneys, and as a result, reducing the volume and number of glomeruli, reducing the volume of the cortex and kidney, and it can improve the structure of kidney tissue in rats exposed to X-ray radiation.
Methods: Twenty-four male rats were randomly divided into 4 groups. The irradiated groups were exposed to 4Gy X-ray. The training groups were exercised 5 times per week for 10 weeks. 24 hours after the last training session, blood samples were collected for evaluation of oxidative and antioxidant factors, and kidney tissue was isolated for stereological studies. The data was analyzed by one-way ANOVA in SPSS 20 software.
Results: In this study, whole-body X-ray irradiation caused a significant increase in kidney volume (P=0.003), cortex volume (P=0.02), glomerular volume (P=0.039), and serum Malondialdehyde (MDA) level (P=0.03). Also, performing the training protocol significantly reduced kidney volume (P=0.03), cortex volume (P=0.04), glomerular volume (P=0.033), and serum MDA level (P=0.02).
Conclusions: Based on this research, it seems that resistance training can lead to a decrease in glomerular filtration by creating adaptation and increasing antioxidant defense and changes in the hemodynamics of the kidneys, and as a result, reducing the volume and number of glomeruli, reducing the volume of the cortex and kidney, and it can improve the structure of kidney tissue in rats exposed to X-ray radiation.
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