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Kafi N, Barjaste Yazdi A, Khajei R, Hoseinabadi M. The Effect of A Period of Resistance Training and Melatonin Supplementation on Sexual Hormone Levels, Pain Intensity, and Sleep Quality in Primary Dysmenorrhea Girls. J Arak Uni Med Sci 2023; 26 (2) :1-10
URL: http://jams.arakmu.ac.ir/article-1-7461-en.html

Introduction: The purpose of this research was to investigate the effect of a period of resistance training and melatonin consumption on sex hormone levels, pain intensity, and sleep quality in girls with primary dysmenorrhea.
Methods: For this purpose, 60 girls with moderate primary dysmenorrhea disorder (score 4-7) were randomly placed in 4 groups: resistance training + melatonin, resistance training + placebo, melatonin supplement group, and control group.  Pain intensity, and sleep quality were assessed by the McGill questionnaire, and the Pittsburgh questionnaire respectively.  10 mg of melatonin was taken daily in two 5 mg capsules and the placebo group received the same amount of carbohydrates in the same capsule.  Weight training, three days a week for eight weeks. This circuit exercise training was in 9 stations and with a maximum of 10-12 repetitions at 30-65% of a maximum repetition in each station.  Each set and repetition was separated by 2-3 minutes and 90 seconds of rest, respectively. The blood sample was taken in the morning, fasting and 5 cc from the brachial vein from the left hand while sitting in the sitting position, and was taken by special kits. Data were analyzed by ANOVA with repeated measures and Bonferroni post hoc test at level P<0.05. All experimental procedures were approved by the Ethics committee of the Sport Sciences Research Institute of Iran (Code: ID IR.IAU.NEYSHABUR.REC.1401.008), Clinical Trial (Code: ID IRCT20230703058653N1) from the Iran Clinical Registration Center and were conducted under the Declaration of Helsinki.
Results: A significant increase in Estrogen (P<0.001) and progesterone (P<0.001) levels in the exercise + supplement group compared to all groups, and in the exercise + placebo group and the supplement group compared to the placebo group was reported. Also, The decrease in Pain intensity (P<0.001) and sleep quality (A decrease in the sleep score means an increase in the sleep quality in the output of the questionnaire) (P<0.001) in the supplement group compared to all groups and in the exercise + placebo group (P<0.05) and the exercise + supplement group compared to the placebo group showed a significant difference.
Conclusions: It seems that synergy of exercise and melatonin has affected the sex hormones level. Also, the melatonin probably helped to improve the sleep quality and pain intensity of the subjects through the adjustment of sex hormones following dysmenorrhea. Also, exercise probably has an effect on the pain intensity and sleep quality through the release of beta-endorphins and the effects of exercise on the menstrual cycle, although the finding are ambiguous.