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1- , m.sadegh@arakmu.ac.ir
Abstract:   (167 Views)
Maternal folate supplement during pregnancy is associated with reduced risk of several fetal neurodevelopmental disorders. However, it is not clear that excess folate intake from diet and supplements can impair neurodevelopment and behavior in offspring. Therefore, the aim of this study was to investigate the effect of chronic and high doses of folic acid before and during pregnancy on spatial learning and avoidance memory of male and female offspring.
In this experimental study, 20 female Wistar rats were randomly divided in four groups of 5 rats. control group receive saline and three others received 500, 1000 and 2000 microgram of folic acid by daily intraperitoneal injection for two weeks before pregnancy and during it. 4 weeks male and female offspring were separated and divided into 8 groups for future spatial learning and avoidance memory.
Spatial learning assessment with water maze revealed that taking dose of 2000 µg of folic acid significantly increased latency and distance to find the hidden plate  in both male and female offspring in compare with control offspring (p<0.05). In addition, retrieval of spatial memory and remaining in the target quadrant were significantly decreased (p<0.05). avoidance memory results also showed that latency to enter the shock chamber 24 and 48 hours after receiving shock in there, significantly decreased in both male and female offspring of 1000 and 2000 compare to their control (p<0.05).
Results of the current study revealed that high and chronic folic acid supplements before and during the pregnancy have the potential to induced neuronal dysfunctions like affecting learning and memory.
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2023/12/31 | Accepted: 2024/01/20

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