Volume 28, Issue 4 (10-2025)
J Arak Uni Med Sci 2025, 28(4): 293-300 |
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Zahmatkeshan S S, Rajabi H. Investigating the Relationship between Serum Adropin Levels and Markers of Renal Function in Active and Inactive Young People. J Arak Uni Med Sci 2025; 28 (4) :293-300
URL: http://jams.arakmu.ac.ir/article-1-7695-en.html
URL: http://jams.arakmu.ac.ir/article-1-7695-en.html
1- PhD Student in Sports Physiology, Faculty of Physical Education, Kharazmi University, Tehran, Iran , zahmatkeshan.ss@gmail.com
2- Professor of Sports Physiology, Faculty of Physical Education, Kharazmi University, Tehran, Iran
2- Professor of Sports Physiology, Faculty of Physical Education, Kharazmi University, Tehran, Iran
Abstract: (249 Views)
Introduction: The aim of this study was to investigate the relationship between serum adropin levels and markers of renal function in active and inactive young people.
Methods: The present research was conducted using a correlational method.Fifty young men and women with an average age of 28.22 ± 2.27 years, height 170 ± 8 cm, and body mass index 24.72 ± 4.88 kg/m² participated in the present study. Subjects were divided into active and inactive groups based on Beck's questionnaire, and 3 cc of blood was taken from their brachial vein to measure levels of adropin, urea, uric acid, creatinine, blood urea nitrogen (BUN), albumin, and total serum protein. The normality of the data was determined through the Kolmogorov-Smirnov test, and the independent t-test was used to compare the mean of the data, and the Pearson correlation coefficient was used to determine the correlation.
Results: Although a strong, positive (r = 0.78 +) and significant (p < 0.05) correlation was observed between adropin and physical activity, the renal function markers did not show a significant difference between the two active and inactive groups. No significant correlation was observed between renal function markers and adropin levels and between renal function markers and physical activity.
Conclusions: With increasing physical activity, the amount of adropin increases, but this increase does not change the levels of renal function markers in healthy people. Therefore, it seems that there is no relationship between adropin levels and renal function markers in healthy young people.
Methods: The present research was conducted using a correlational method.Fifty young men and women with an average age of 28.22 ± 2.27 years, height 170 ± 8 cm, and body mass index 24.72 ± 4.88 kg/m² participated in the present study. Subjects were divided into active and inactive groups based on Beck's questionnaire, and 3 cc of blood was taken from their brachial vein to measure levels of adropin, urea, uric acid, creatinine, blood urea nitrogen (BUN), albumin, and total serum protein. The normality of the data was determined through the Kolmogorov-Smirnov test, and the independent t-test was used to compare the mean of the data, and the Pearson correlation coefficient was used to determine the correlation.
Results: Although a strong, positive (r = 0.78 +) and significant (p < 0.05) correlation was observed between adropin and physical activity, the renal function markers did not show a significant difference between the two active and inactive groups. No significant correlation was observed between renal function markers and adropin levels and between renal function markers and physical activity.
Conclusions: With increasing physical activity, the amount of adropin increases, but this increase does not change the levels of renal function markers in healthy people. Therefore, it seems that there is no relationship between adropin levels and renal function markers in healthy young people.
References
1. Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metab. 2008;8(6):468-81. pmid: 19041763 doi: 10.1016/j.cmet.2008.10.011
2. Zhang S, Chen Q, Lin X, Chen M, Liu Q. A review of adropin as the medium of dialogue between energy regulation and immune regulation. Oxid Med Cell Longev. 2020;2020: 3947806. pmid: 32190172 doi: 10.1155/2020/3947806
3. Ganesh‐Kumar K, Zhang J, Gao S, Rossi J, McGuinness OP, Halem HH, et al. Adropin deficiency is associated with increased adiposity and insulin resistance. Obesity (Silver Spring). 2012;20(7):1394-402. pmid: 22318315 doi: 10.1038/oby.2012.31.
4. Aydin S, Kuloglu T, Aydin S, Eren MN, Yilmaz M, Kalayci M, et al. Expression of adropin in rat brain, cerebellum, kidneys, heart, liver, and pancreas in streptozotocin-induced diabetes. Mol Cell Biochem. 2013; 380(1-2):73-81. pmid: 23620340 doi: 10.1007/s11010-013-1660-4. .
5. Jasaszwili M, Billert M, Strowski MZ, Nowak KW, Skrzypski M. Adropin as a fat-burning hormone with multiple functions—Review of a decade of research. Molecules. 2020;25(3):549. pmid: 32012786 doi: 10.3390/molecules25030549
6. Maciorkowska M, Musiałowska D, Małyszko J. Adropin and irisin in arterial hypertension, diabetes mellitus and chronic kidney disease. Adv Clin Exp Med. 2019;28(11): ):1571-5. pmid: 31756066 doi: 10.17219/acem/104551.
7. Akcilar R, Kocak FE, Simsek H, Akcilar A, Bayat Z, Ece E, Kokdasgil H. Antidiabetic and Hypolipidemic Effects of Adropin in Streptozotocin-induced Type 2 Diabetic Rats. Bratisl Lek Listy. 2016;117(2):100-5. pmid: 26830041 doi: 10.4149/bll_2016_020.
8. Lian W, Gu X, Qin Y, Zheng X. Elevated plasma levels of adropin in heart failure patients. Intern Med. 2011;50(15):1523-7. pmid: 21804276 doi: 10.2169/internalmedicine.50.5163
9. Diwan V, Brown L, Gobe GC. Adenine‐induced chronic kidney disease in rats. Nephrology (Carlton). 2018;23(1):5-11. pmid: 29030945 doi: 10.1111/nep.13180
10. Topuz M, Celik A, Aslantas T, Demir AK, Aydin S, Aydin S. Plasma adropin levels predict endothelial dysfunction like flow-mediated dilatation in patients with type 2 diabetes mellitus. J Investig Med. 2013;61(8):1161-4. pmid: 24113736 doi: 10.2310/JIM.0000000000000003
11. Celik A, Balin M, Kobat MA, Erdem K, Baydas A, Bulut M, et al. Deficiency of a new protein associated with cardiac syndrome X; called adropin. Cardiovasc Ther. 2013;31(3):174-8. pmid: 23356444 doi: 10.1111/1755-5922.12025.
12. Yu H-y, Zhao P, Wu M-c, Liu J, Yin W. Serum adropin levels are decreased in patients with acute myocardial infarction. Regul Pept. 2014;190:46-9. pmid: 24731968 doi: 10.1016/j.regpep.2014.04.001
13. Wu L, Fang J, Chen L, Zhao Z, Luo Y, Lin C, Fan L. Low serum adropin is associated with coronary atherosclerosis in type 2 diabetic and non-diabetic patients. Clin Chem Lab Med. 2014;52(5):751-8. pmid: 24323892 doi: 10.1515/cclm-2013-0844
14. Mushala BA, Scott I. Adropin: a hepatokine modulator of vascular function and cardiac fuel metabolism. Am J Physiol Heart Circ Physiol. 2021;320(1):H238-H44. pmid: 33216612 doi: 10.1152/ajpheart.00449.2020
15. Kasiske B, Cosio FG, Beto J, Bolton K, Chavers BM, Grimm Jr R, et al. Clinical practice guidelines for managing dyslipidemias in kidney transplant patients: a report from the Managing Dyslipidemias in Chronic Kidney Disease Work Group of the National Kidney Foundation Kidney Disease Outcomes Quality Initiative. Am J Transplant. 2004;4(Suppl 7):13-53. pmid: 15027968 doi: 10.1111/j.1600-6135.2004.0355.x.
16. Stopic B, Medic-Brkic B, Savic-Vujovic K, Davidovic Z, Todorovic J, Dimkovic N. Biomarkers and predictors of adverse Cardiovascular events in different stages of chronic kidney disease. Dose Response. 2022;20(3):15593258221127568. pmid: 36118679 doi: 10.1177/15593258221127568
17. Waziri B, Duarte R, Naicker S. Chronic kidney disease–mineral and bone disorder (CKD-MBD): current perspectives. Int J Nephrol Renovasc Dis. 2019;12:263-76. pmid: 31920363 doi: 10.2147/IJNRD.S191156
18. Voelkl J, Lang F, Eckardt K-U, Amann K, Kuro-o M, Pasch A, et al. Signaling pathways involved in vascular smooth muscle cell calcification during hyperphosphatemia. Cell Mol Life Sci. 2019;76(11):2077-91. pmid: 30887097 doi: 10.1007/s00018-019-03054-z
19. D'Arrigo G, Mallamaci F, Pizzini P, Leonardis D, Tripepi G, Zoccali C. CKD-MBD biomarkers and CKD progression: An analysis by the joint model. Nephrol Dial Transplant. 2023;38(4):932-8. pmid: 35790138 doi: 10.1093/ndt/gfac212
20. Niskanen LK, Laaksonen DE, Nyyssönen K, Alfthan G, Lakka H-M, Lakka TA, Salonen JT. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med. 2004;164(14):1546-51. pmid: 15277287 doi: 10.1001/archinte.164.14.1546
21. Fang J, Alderman MH. Serum uric acid and cardiovascular mortality: the NHANES I epidemiologic follow-up study, 1971-1992. JAMA. 2000;283(18):2404-10. pmid: 10815083 doi: 10.1001/jama.283.18.2404
22. Culleton BF, Larson MG, Kannel WB, Levy D. Serum uric acid and risk for cardiovascular disease and death: the Framingham Heart Study. Ann Intern Med. 1999;131(1):7-13. pmid: 10391820 doi: 10.7326/0003-4819-131-1-199907060-00003
23. Lim HE, Kim SH, Kim EJ, Kim JW, Rha SW, Seo HS, Park CG. Clinical value of serum uric acid in patients with suspected coronary artery disease. Korean J Intern Med. 2010;25(1):21-6. pmid: 20195399 doi: 10.3904/kjim.2010.25.1.21.
24. Amsalem Y, Garty M, Schwartz R, Sandach A, Behar S, Caspi A, et al. Prevalence and significance of unrecognized renal insufficiency in patients with heart failure. Eur Heart J. 2008;29(8):1029-36. pmid: 18339607 doi: 10.1093/eurheartj/ehn102
25. Lehto S, Niskanen L, Ronnemaa T, Laakso M. Serum uric acid is a strong predictor of stroke in patients with non–insulin-dependent diabetes mellitus. stroke. 1998;29(3):635-9. pmid: 9506605 doi: 10.1161/01.str.29.3.635.
26. Zeighami Mohammadi S, Asgharzadeh Haghighi S. The relationship between Serum creatinine with length of hospital stay and mortality in heart failure patients [in Persian]. Journal of Urmia Nursing & Midwifery Faculty. 2011;9(3).
27. Clyne N, Anding-Rost K. Exercise training in chronic kidney disease—effects, expectations and adherence. Clin Kidney J. 2021;14(Suppl 2):ii3-ii14. pmid: 33981415 doi: 10.1093/ckj/sfab012
28. Kajbafvala M, ShahAli S, Ebrahimi Takamjani I, Ashnagar Z, Hosseini R, Shahabi S, Hejazi A. Effect of exercise training on functional capacity, muscle strength, exercise capacity, dialysis efficacy and quality of life in children and adolescents with chronic kidney disease: a systematic review and meta-analysis. Int Urol Nephrol. 2024;56(6):1939-51. pmid: 38055100 doi: 10.1007/s11255-023-03887-5.
29. Moreira JB, Wohlwend M, Wisløff U. Exercise and cardiac health: physiological and molecular insights. Nat Metab. 2020;2(9):829-39. pmid: 32807982 doi: 10.1038/s42255-020-0262-1
30. Valenzuela PL, Ruilope LM, Santos-Lozano A, Wilhelm M, Kränkel N, Fiuza-Luces C, Lucia A. Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation. Eur Heart J. 2023;44(21):1874-89. pmid: 37005351 doi: 10.1093/eurheartj/ehad170
31. Ciumărnean L, Milaciu MV, Negrean V, Orășan OH, Vesa SC, Sălăgean O, et al. Cardiovascular risk factors and physical activity for the prevention of cardiovascular diseases in the elderly. Int J Environ Res Public Health. 2021;19(1):207. pmid: 35010467 doi: 10.3390/ijerph19010207.
32. Nakamura K, Sasaki T, Yamamoto S, Hayashi H, Ako S, Tanaka Y. Effects of exercise on kidney and physical function in patients with non-dialysis chronic kidney disease: a systematic review and meta-analysis. Sci Rep. 2020;10(1):18195. pmid: 33097801 doi: 10.1038/s41598-020-75405-x
33. Sato K, Nishijima T, Yokokawa T, Fujita S. Acute bout of exercise induced prolonged muscle glucose transporter-4 translocation and delayed counter-regulatory hormone response in type 1 diabetes. PLoS One. 2017;12(6):e0178505. pmid: 28570686 doi: 10.1371/journal.pone.0178505
34. Fujie S, Hasegawa N, Kurihara T, Sanada K, Hamaoka T, Iemitsu M. Association between aerobic exercise training effects of serum adropin level, arterial stiffness, and adiposity in obese elderly adults. Appl Physiol Nutr Metab. 2017;42(1):8-14. pmid: 27897440 doi: 10.1139/apnm-2016-0310
35. Zhang H, Jiang L, Yang Y-J, Ge R-K, Zhou M, Hu H, et al. Aerobic exercise improves endothelial function and serum adropin levels in obese adolescents independent of body weight loss. Sci Rep. 2017;7(1):17717. pmid: 29255252 doi: 10.1038/s41598-017-18086-3
36. Sharabiani S, Rajabi H, Mo'tamedi P, Dehkhada M, Kaviani M. The effect of eight weeks of combined exercise on serum adipine and nitric oxide levels in high pressure menopausal women [in Persian]. J Physiol Manag Res Sport Round. 2019;11(1):129-43.
37. Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982;36(5):936-42. pmid: 7137077 doi: 10.1093/ajcn/36.5.936
38. Straznicky NE, Grima MT, Lambert EA, Eikelis N, Dawood T, Lambert GW, et al. Exercise augments weight loss induced improvement in renal function in obese metabolic syndrome individuals. J Hypertens. 2011;29(3):553-64. pmid: 21119532 doi: 10.1097/HJH.0b013e3283418875
39. Pourjafarian J, Behboudi Tabrizi L, Mohammadnejadpanahkandi Y, Salehi Kordabad F, Kazemzadeh Y. The effect of 12 weeks of plyometric training on serum creatinine and uric acid levels in young male bodybuilders consuming whey protein [in Persian]. Community Health. 2019;13(1):11-20. doi: 10.22123/chj.2019.165564.1216
40. Dehghani F, Daryanoush F, Mohammadi N, Dadvand SS. The effect of 12 weeks of aerobic exercise on changes in creatinine, blood urea nitrogen, fasting blood sugar, and triglycerides in obese women with type 2 diabetes [in Persian]. Movement and Behavioral Sciences. 2019;2(2):97-104.
41. Fujie S, Hasegawa N, Sato K, Fujita S, Sanada K, Hamaoka T, Iemitsu M. Aerobic exercise training-induced changes in serum adropin level are associated with reduced arterial stiffness in middle-aged and older adults. Am J Physiol Heart Circ Physiol. 2015;309(10):H1642-7. pmid: 26371163 doi: 10.1152/ajpheart.00338.2015
42. Hosseini H, Fatolahi H. The effect of aerobic water-based training on adropin levels, insulin resistance and lipid profile in ageing men [in Persian]. Yafteh. 2019;21(1):99-110.
43. Nourbakhsh R, Ravasi A, Soori R. The effect of combined training and l-arginine supplement on the serum levels of adropin, VEGFR-2, and nitric oxide in post-menopausal hypertensive women [in Persian]. Women’s Health Bulletin. 2022;14(3):40-51. doi: 10.32592/nkums.14.3.40
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