Volume 27, Issue 3 (7-2024)                   J Arak Uni Med Sci 2024, 27(3): 164-170 | Back to browse issues page


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Yousefvand Z, Rahmati M, Mirnasuri R. The Effect of 12 Weeks of Resistance Training on Serum Levels of Myonectin and FGF-21 in Inactive Middle-aged Men. J Arak Uni Med Sci 2024; 27 (3) :164-170
URL: http://jams.arakmu.ac.ir/article-1-7698-en.html
1- Department of Physical Education, Faculty of Literature and Human Sciences, Lorestan University, Lorestan, Iran
2- Department of Physical Education, Faculty of Literature and Human Sciences, Lorestan University, Lorestan, Iran , Rahmati.mas@lu.ac.ir
3- Sports Physiology, Department of Physical Education, Faculty of Literature and Human Sciences, Lorestan University, Lorestan, Iran
Abstract:   (290 Views)
Introduction: Considering the synthesis and release of myokines from muscle tissue during exercise and the relationship of myokines with the development of strength and increase in muscle volume, the purpose of this study is to investigate 12 weeks of resistance training on the serum levels of myonectin and FGF- There were 21 middle-aged men.
Methods: In a semi-experimental study, 40 middle-aged men of Arak city (mean age 38.27 ± 6.02 years, weight 77.12 ± 11.23 kg, height 174.05 ± 7.22 cm) were selected and randomly placed in two resistance training groups (20 people) and control (20 people). The training group performed 12 weeks of resistance training 3 times a week with an intensity of 65-80% of maximum strength. Blood was taken from all the subjects 48 hours before and after the intervention, and serum levels of myonectin and FGF-21 were checked by the ELISA method. After checking the normality of the data, they were analyzed by the correlation t-test and independent t-test at a significance level of less than 0.05.
Results: Resistance training caused a significant increase in the serum level of myonectin (P = 0.001) and the serum level of FGF-21 (P = 0.001) and also decreased the percentage of fat (P = 0.417) in middle-aged men.
Conclusions: According to the results of this study, it seems that resistance training can have positive adaptation by increasing the serum levels of myonectin and FGF-21 in the regulation of muscle mass, hypertrophy process, angiogenesis process, and Improve the body's metabolism.
Full-Text [PDF 1266 kb]   (150 Downloads)    
Type of Study: Original Atricle | Subject: General
Received: 2024/04/25 | Accepted: 2024/06/19

References
1. Alizadeh Pahlavani H. Exercise therapy for people with sarcopenic obesity: myokines and adipokines as effective actors. Front Endocrinol (Lausanne). 2022;13:811751. pmid: 35250869 doi: 10.3389/fendo.2022.811751
2. Waldemer‐Streyer RJ, Kim D, Chen J. Muscle cell‐derived cytokines in skeletal muscle regeneration. FEBS J. 2022;289(21):6463-83. pmid: 35073461 doi: 10.1111/febs.16372
3. Schnyder S, Handschin C. Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise. Bone. 2015;80:115-25. pmid: 26453501 doi: 10.1016/j.bone.2015.02.008
4. Carson BP. The potential role of contraction-induced myokines in the regulation of metabolic function for the prevention and treatment of type 2 diabetes. Front Endocrinol (Lausanne). 2017;8:97. pmid: 28512448 doi: 10.3389/fendo.2017.00097
5. Lee JH, Jun H-S. Role of myokines in regulating skeletal muscle mass and function. Front Physiol. 2019;10:42. pmid: 30761018 doi: 10.3389/fphys.2019.00042
6. Gamas L, Matafome P, Seiça R. Irisin and myonectin regulation in the insulin resistant muscle: implications to adipose tissue: muscle crosstalk. J Diabetes Res. 2015;2015:359159. pmid: 26075283 doi: 10.1155/2015/359159
7. Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW. Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem. 2012;287(15):11968-80. pmid: 22351773 doi: 10.1074/jbc.M111.336834
8. Seldin MM, Wong GW. Regulation of tissue crosstalk by skeletal muscle-derived myonectin and other myokines. Adipocyte. 2012;1(4):200-2. pmid: 23700534 doi: 10.4161/adip.20877
9. Ozaki Y, Ohashi K, Otaka N, Kawanishi H, Takikawa T, Fang L, et al. Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway. Nat Commun. 2023;14(1):4675. doi: 10.1038/s41467-023-40435-2
10. Halling JF, Jessen H, Nøhr-Meldgaard J, Buch BT, Christensen NM, Gudiksen A, et al. PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab. 2019;317(3):E513-E525. pmid: 31265325 doi: 10.1152/ajpendo.00059.2019
11. Seldin MM, Lei X, Tan SY, Stanson KP, Wei Z, Wong GW. Skeletal muscle-derived myonectin activates the mammalian target of rapamycin (mTOR) pathway to suppress autophagy in liver. J Biol Chem. 2013;288(50):36073-82. pmid: 24187137 doi: 10.1074/jbc.M113.500736
12. Bonaldo P, Sandri M. Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech. 2013;6(1):25-39. pmid: 23268536 doi: 10.1242/dmm.010389
13. Peterson JM, Mart R, Bond CE. Effect of obesity and exercise on the expression of the novel myokines, Myonectin and Fibronectin type III domain containing 5. PeerJ. 2014;2:e605. pmid: 25289190 doi: 10.7717/peerj.605
14. Seo JA, Kim NH. Fibroblast growth factor 21: a novel metabolic regulator. Diabetes & Metabolism Journal. 2012;36(1):26-8. DOI: 10.4093/dmj.2012.36.1.26
15. Itoh N. FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases. Front Endocrinol (Lausanne). 2014;5:107. pmid: 25071723 doi: 10.3389/fendo.2014.00107
16. Domouzoglou EM, Naka KK, Vlahos AP, Papafaklis MI, Michalis LK, Tsatsoulis A, Maratos-Flier E. Fibroblast growth factors in cardiovascular disease: The emerging role of FGF21. Am J Physiol Heart Circ Physiol. 2015;309(6):H1029-H38. pmid: 26232236 doi: 10.1152/ajpheart.00527.2015
17. Pauly M, Daussin F, Burelle Y, Li T, Godin R, Fauconnier J, et al. AMPK activation stimulates autophagy and ameliorates muscular dystrophy in the mdx mouse diaphragm. Am J Pathol. 2012;181(2):583-92. pmid: 22683340 doi: 10.1016/j.ajpath.2012.04.004
18. Kim H-J, Song W. Resistance training increases fibroblast growth factor-21 and irisin levels in the skeletal muscle of Zucker diabetic fatty rats. J Exerc Nutrition Biochem. 2017;21(3):50-4. pmid: 29036766 doi: 10.20463/jenb.2017.0008
19. Hojman P, Pedersen M, Nielsen AR, Krogh-Madsen R, Yfanti C, Åkerstrom T, et al. Fibroblast growth factor-21 is induced in human skeletal muscles by hyperinsulinemia. Diabetes. 2009;58(12):2797-801. pmid: 19720803 doi: 10.2337/db09-0713
20. Blocquiaux S, Gorski T, van Roie E, Ramaekers M, van Thienen R, Nielens H, et al. The effect of resistance training, detraining and retraining on muscle strength and power, myofibre size, satellite cells and myonuclei in older men. Exp Gerontol. 2020;133:110860. pmid: 32017951 doi: 10.1016/j.exger.2020.110860
21. Safarzade A, Moazam-Vahid L. Effect of eight weeks resistance training on plasma myonectin concentration in obese men [in Persian]. Journal of Applied Exercise Physiology. 2016;12(24):119-28. doi: 10.22080/jaep.2017.1466
22. Lim S, Choi SH, Koo BK, Kang SM, Yoon JW, Jang HC, et al. Effects of aerobic exercise training on C1q tumor necrosis factor α-related protein isoform 5 (myonectin): association with insulin resistance and mitochondrial DNA density in women. J Clin Endocrinol Metab. 2012;97(1):E88-E93. pmid: 22031510 doi: 10.1210/jc.2011-1743
23. Shahidi F, Kashef M. The effect of 4 and 6 weeks of resistance training on serum levels of myonectin and IGF-1 in sedentary young men [in Persian]. Razi J Med Sci. 2019;25(10):31-37.
24. Khadivi Borujeny A, Marandi M, Haghjooy Javanmard S, Rajabi H, Khadivi Burojeny Z, Khorshidi Behzadi M. Effect of eight weeks of resistance training on some signaling factors affecting on the satellite cells in wistar rats [in Persian].
25. J Isfahan Med Sch. 2012;30(207):1500-11.
26. Yang SJ, Hong HC, Choi HY, Yoo HJ, Cho GJ, Hwang TG, et al. Effects of a three‐month combined exercise programme on
27. fibroblast growth factor 21 and fetuin‐A levels and arterial stiffness in obese women. Clin Endocrinol (Oxf). 2011;75(4):464-9. pmid: 21521346 doi: 10.1111/j.1365-2265.2011.04078.x
28. Berglund ED, Kang L, Lee-Young RS, Hasenour CM, Lustig DG, Lynes SE, et al. Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARα and FGF21 transcripts in vivo. Am J Physiol Endocrinol Metab. 2010;299(4):E607-E14. pmid: 20663988 doi: 10.1152/ajpendo.00263.2010
29. Tidball JG. Mechanical signal transduction in skeletal muscle growth and adaptation. J Appl Physiol (1985). 2005;98(5):1900-8. pmid: 15829723 doi: 10.1152/japplphysiol.01178.2004
30. Hanssen K, Kvamme N, Nilsen T, Rønnestad B, Ambjørnsen I, Norheim F, et al. The effect of strength training volume on satellite cells, myogenic regulatory factors, and growth factors. Scand J Med Sci Sports. 2013;23(6):728-39. pmid: 22417199 doi: 10.1111/j.1600-0838.2012.01452.x
31. Mukund K, Subramaniam S. Skeletal muscle: A review of molecular structure and function, in health and disease. Am J Physiol Endocrinol Metab. 2020;12(1):e1462. pmid: 31407867 doi: 10.1002/wsbm.1462

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