Volume 29, Issue 2 (5-2026)
J Arak Uni Med Sci 2026, 29(2): 99-106 |
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Timouri M, Fathi M, Bahrami M. Effect of Trenbolone Steroid and CJC Peptide During Two Months of Resistance Training on Liver Damage in Adult Male Rats: An Experimental Study. J Arak Uni Med Sci 2026; 29 (2) :99-106
URL: http://jams.arakmu.ac.ir/article-1-7735-en.html
URL: http://jams.arakmu.ac.ir/article-1-7735-en.html
1- MSc in exercise physiology, faculty of humanities, Lorestan University, Khorramabad, Iran
2- Professor, Physiology of Sport, Faculty of Humanities, Lorestan University, Khorramabad, Iran ,fathi.m@lu.ac.ir
3- Assistant Professor, Sports Physiology, Faculty of Human Sciences, Lorestan University, Khorramabad, Iran
2- Professor, Physiology of Sport, Faculty of Humanities, Lorestan University, Khorramabad, Iran ,
3- Assistant Professor, Sports Physiology, Faculty of Human Sciences, Lorestan University, Khorramabad, Iran
Abstract: (348 Views)
Introduction: The use of steroids and other supplements may affect body tissues including the liver, this study aimed the effect of trenbolone steroid and CJC peptide during two months of resistance training on liver damage in adult male rats.
Methods: 40 male Wistar rats (weight 180-220 grams) were randomly divided into four groups: control, exercise-trenbolone, exercise-CJC and exercise. Resistance training was performed for eight weeks and three sessions per week, and at the same time as the training, targeted injections were also performed for the trenbolone and CJC groups once a week through gluteal and thigh muscles in the amount of five micrograms per kilogram of body weight. the weight, the ratio of liver weight to the weight of samples and liver damage were measured using an optical microscope. One-way analysis of variance and Tukey's follow-up test at the level (P<0.05) were used to analyze the data.
Results: The findings showed that the groups receiving trenbolone and CJC peptide did not have a significant increase in weight compared to other groups (P≥0.05). However, the ratio of liver weight to body weight in the trenbolone group was significant compared to the training and control groups (P<0.05). Vascular hyperemia, fat vacuoles, inflammation and degeneration in the liver of the trenbolone and CJC peptide groups were significantly higher than the control and exercise groups (P≤0.05).
Conclusions: Based on the findings of this study, signs of liver damage were found in the samples that consumed these anabolic steroids.
Methods: 40 male Wistar rats (weight 180-220 grams) were randomly divided into four groups: control, exercise-trenbolone, exercise-CJC and exercise. Resistance training was performed for eight weeks and three sessions per week, and at the same time as the training, targeted injections were also performed for the trenbolone and CJC groups once a week through gluteal and thigh muscles in the amount of five micrograms per kilogram of body weight. the weight, the ratio of liver weight to the weight of samples and liver damage were measured using an optical microscope. One-way analysis of variance and Tukey's follow-up test at the level (P<0.05) were used to analyze the data.
Results: The findings showed that the groups receiving trenbolone and CJC peptide did not have a significant increase in weight compared to other groups (P≥0.05). However, the ratio of liver weight to body weight in the trenbolone group was significant compared to the training and control groups (P<0.05). Vascular hyperemia, fat vacuoles, inflammation and degeneration in the liver of the trenbolone and CJC peptide groups were significantly higher than the control and exercise groups (P≤0.05).
Conclusions: Based on the findings of this study, signs of liver damage were found in the samples that consumed these anabolic steroids.
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