Volume 28, Issue 3 (8-2025)
J Arak Uni Med Sci 2025, 28(3): 211-218 |
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Fatahian R, Karimi B, Hosseini S R, Forouhar Majd K, Hatempour A. An Investigation into the Histological Impacts of Thiamine on Renal Architecture in the Presence of Copper Oxide Nanoparticles. J Arak Uni Med Sci 2025; 28 (3) :211-218
URL: http://jams.arakmu.ac.ir/article-1-7750-en.html
URL: http://jams.arakmu.ac.ir/article-1-7750-en.html
Rahmatallah Fatahian1 
, Behnaz Karimi2 , Seyed Reza Hosseini3 , Kianoush Forouhar Majd3 , Ayatallah Hatempour4
, Behnaz Karimi2 , Seyed Reza Hosseini3 , Kianoush Forouhar Majd3 , Ayatallah Hatempour4
1- Associate Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran , fatahian_1349@gmail.com
2- Associate Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
3- PhD Student in Veterinary Medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
4- MSc of Basic Sciences Department of the Physiopharmacology Laboratory, Shahrekord, Iran
2- Associate Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
3- PhD Student in Veterinary Medicine, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran
4- MSc of Basic Sciences Department of the Physiopharmacology Laboratory, Shahrekord, Iran
Abstract: (277 Views)
Introduction: The study discusses the impact of thiamine on the kidney tissue of rats that have been exposed to copper oxide nanoparticles. The research examined how thiamine correlates with the level of kidney damage caused by the intrusion of nanoparticles.
Methods: In this experimental study, forty male Wistar rats were randomly divided into four groups (10 rats per group). Two groups of rats were used as the control group (I) and the thiamine group (II). Rats of group III were administered an intraperitoneal injection of 25 mg/kg body weight of copper oxide nanoparticles for 14 days. Rats in group IV received the same dose of copper oxide nanoparticles along with thiamine (30 mg/kg body weight).
Results: The histopathological findings showed disruption of the arrangement of convoluted tubules and their disintegration and widening of the tubular lumen, cell separation and tubular necrosis in the majority of the renal tubules in-group III. In the group treated with copper oxide nanoparticles along with thiamine (IV), the pathological changes were slight and the majority of the tubules had retained normal structure. Statistically significant differences in the levels of some serum biochemical parameters (catalase, superoxide dismutase, TBARS, and TAC) were observed in groups III and IV on day 14 when compared to the control group.
Conclusions: This study demonstrated that thiamine can be utilized as an effective compound to reduce the damage caused by nanoparticles to kidney tissue and may lead to significant improvement in the health of kidney tissue in individuals suffering from damage caused by these nanoparticles.
Methods: In this experimental study, forty male Wistar rats were randomly divided into four groups (10 rats per group). Two groups of rats were used as the control group (I) and the thiamine group (II). Rats of group III were administered an intraperitoneal injection of 25 mg/kg body weight of copper oxide nanoparticles for 14 days. Rats in group IV received the same dose of copper oxide nanoparticles along with thiamine (30 mg/kg body weight).
Results: The histopathological findings showed disruption of the arrangement of convoluted tubules and their disintegration and widening of the tubular lumen, cell separation and tubular necrosis in the majority of the renal tubules in-group III. In the group treated with copper oxide nanoparticles along with thiamine (IV), the pathological changes were slight and the majority of the tubules had retained normal structure. Statistically significant differences in the levels of some serum biochemical parameters (catalase, superoxide dismutase, TBARS, and TAC) were observed in groups III and IV on day 14 when compared to the control group.
Conclusions: This study demonstrated that thiamine can be utilized as an effective compound to reduce the damage caused by nanoparticles to kidney tissue and may lead to significant improvement in the health of kidney tissue in individuals suffering from damage caused by these nanoparticles.
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