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Volume 16, Issue 9 (12-2013)                   J Arak Uni Med Sci 2013, 16(9): 90-100 | Back to browse issues page

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Nomani H, Aidy A, Hagh Nazari L, Reissi D. The Association Between GSTP1 A/G Polymorphism and Oxidative Stress with End Stage Renal Disease (ESRD) in Kermanshah. J Arak Uni Med Sci. 2013; 16 (9) :90-100
URL: http://jams.arakmu.ac.ir/article-1-2416-en.html
1- Department of Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Department of Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran , Aliaidi11@yahoo.com
3- Kidney Transplantation Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:   (9298 Views)

Background: End stage renal disease or ESRD is a progressive and irreversible deterioration in renal function in which the body’s ability to maintain metabolic and fluid and electrolyte balance fails. Glutathione s-transfrase P1 is member of multigenic family which have essential role in cells as an antioxidant. In this study we investigated the polymorphism of GSTP1 genotypes and oxidative stress in ESRD patients and compare with control subjects to determine the possible relation between polymorphism of this enzyme and ESRD.

Materials and Methods: We select 136 ESRD patients and 137 control cases (without kidney disease). GST P1 polymorphism were determined with PCR-RFLP. Level of MDA was measured by HPLC apparatus.

Results: Genotypes distribution of GSTP1 A/G polymorphism to AA, AG and GG genotypes in control group were 70(51.1%), 56(40.9%) and 11(8%) and In diabetic group 74(55.6%), 50(37.6%) and 9(6.8%), respectively (p=0.744). MDA levels in ESRD patients was higher than control group (p<0.001).

Conclusion: GSTP1 A/G polymorphism between two groups and each groups was not statistically significant with ESRD, probably this enzyme has a protective role in the risk of ESRD.

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Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2013/07/15 | Accepted: 2013/11/20

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