Volume 17, Issue 6 (9-2014)                   J Arak Uni Med Sci 2014, 17(6): 19-30 | Back to browse issues page

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Rezayof A, Zarrindast M R, Darbandi N. The Inhibition of Nucleus Acumbens Cholinergic Receptors Decreased Memory Retention in Rat. J Arak Uni Med Sci. 2014; 17 (6) :19-30
URL: http://jams.arakmu.ac.ir/article-1-2927-en.html
1- Department of Animal Physiology, College of Science, University of Tehran, Tehran, Iran
2- Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Biology, Faculty of Science, Arak University, Arak, Iran , N-Darbandi@araku.ac.ir
Abstract:   (3448 Views)

Background: It is well known that morphine influence learning and memory processes. The Nucleus accumbens (N.ac) which has an important role in reward participates in morphine-induced impairment of memory retention. Considering the cholinergic system is involved in the effects of morphine on learning and memory, in the present study, the effects of intra-N.ac injections of acetylcholine receptor antagonists alone or with morphine on memory retention and morphine-induced memory has been investigated in rats.

Materials and Methods: In this original research animals were bilaterally cannulated in the N.ac and a step-through passive avoidance task was used for the assessment of memory retention .

Results: Post-training subcutaneous administration of morphine dose dependently decreased the learning and induced amnesia. The administration of the same dose of morphine as pre-test treatment induced state-dependent learning. Pre-test intra- N.ac administration of atropine, scopolamine and mecamylamine in different doses alone cannot affect on memory retention. While, pretest intra- N.ac injection of these drugs before the administration of morphine dose dependently inhibited morphine state-dependent learning. The level of statistical significance was set at p<0.05 .

Conclusion: The processes of learning in animals can be affected by morphine and the opioids produce state-dependent learning. Moreover, it can be concluded that inactivation of the muscarinic and nicotinic acethylcoline receptors in the N.ac are involved in mediating morphine state-dependent learning.

Full-Text [PDF 633 kb]   (1453 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2014/05/4 | Accepted: 2014/08/19

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