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Volume 19, Issue 1 (4-2016)                   J Arak Uni Med Sci 2016, 19(1): 63-70 | Back to browse issues page

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Farazi A A, Hoseini S D, Ghaznavirad E, Sadekhoo S. Antibiotic Susceptibility of Brucella Melitensis in Markazi Province (2014). J Arak Uni Med Sci. 2016; 19 (1) :63-70
URL: http://jams.arakmu.ac.ir/article-1-3963-en.html
1- Department of Infectious Diseases, Infectious Disease Research Center, Arak University of Medical Sciences, Arak, Iran. , farazialiasghar@yahoo.com
2- Razi Vaccine and Serum Research Center, Arak Branch, Arak, Iran.
3- Department of Microbiology, Arak University of Medical Sciences, Arak, Iran.
4- Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran.
Abstract:   (3859 Views)

Background: Brucellosis is one of the most important diseases among humans and animals. Clinical management of brucellosis due to an increased rate of treatment failure and recurrence is extremely worrying. The aim of this study was to determine the antimicrobial susceptibility pattern of the brucella isolates.

Materials and Methods: From April to September 2014 a total of 30 brucella isolates that were cultured on brucella agar has been studied. The species identification was carried out and to determine the effect of antibiotics on bacteria antibiogram testing was performed by disk diffusion.

Results: In this study, 30 brucella strains were isolated from cultured specimens and antibiogram testing was performed. All microbial positive specimens were sequenced by PCR. All isolates were Brucella melitensis. According to the tests, suceptibility to tetracycline, minocycline, gentamicin, tigecyclin was 100%, to doxycycline 93.3%, co-amoxiclave 66.7%, rifampin 44.7%, streptomycin 86.7%, ciprofloxacin 80%, cotrimoxazole 76.7% and ceftriaxone 73.3%.

Conclusion: This study shows that the predominant strain in our patients was Brucella melitensis. Also, due to high levels of resistance to rifampin to use the other effective drugs like gentamicin, streptomycin, ciprofloxacin or cotrimoxazole in combination with doxycycline or tetracycline.

Full-Text [PDF 639 kb]   (1236 Downloads)    
Type of Study: Original Atricle | Subject: Infection
Received: 2015/09/15 | Accepted: 2015/11/9

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