Write your message
Volume 19, Issue 8 (11-2016)                   J Arak Uni Med Sci 2016, 19(8): 67-78 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fattahi E, Hemayatkhah Jahromi V. Protective Effects of Eryngium Caucasicum Trautv Hydroalcholic Extract on Tricyclazole Induced Hepatotoxicity in Mice. J Arak Uni Med Sci. 2016; 19 (8) :67-78
URL: http://jams.arakmu.ac.ir/article-1-4553-en.html
1- Department of Biology, Ayatollah Amoli Branch Islamic Azad University, Amol, Iran , esmail_fattahy@yahoo.com
2- Department of Biology, Jahrom Branch, Islamic Azad University, Jahrom, Iran
Abstract:   (2336 Views)


Background: Eryngium caucasicum Trautv has antioxidant properties due to the presence of flavonoids and phenolic compounds. So, the present study was done to investigate the protective effects of Eryngium caucasicum Trautv extract on tricyclazole induced hepatotoxicity in mice.

Materials and Methods: In this experimental study, 42 mice were divided into 6 groups including control, sham, tricyclazole (TCZ) and three experimental groups. The mice in the tricyclazole group, received 50 mg/kg TCZ via intraperitoneal injection and experimental groups 2, 3 and 4 received respectively 100,200and 400 mg/kg of extract via gavage for 4 weeks and 2 days per week.  The sham group received only sterile water. At the end, serum levels of ALT, AST and ALP, serum concentration of albumin and total bilirubin were measured. Also, total phenolic compounds and flavonoids in the extract were measured. Data were analyzed by using ANOVA.

Results: Tricyclazole increased serum levels of aminotransferase, phosphatase alkaline and total bilirubin and decreased serum concentration of albumin. But, treatment with extract decreased liver enzymes and bilirubin and increased levels of albumin (p<0.05). Amount of total phenolic compounds and the flavonoids were measured 91.16 mg/gr galicacid in extract and 84.48 mg/gr quercetin in extract, respectively.

Conclusion: The results demonstrated that Eryngium caucasicum Trautv extract due to the presence of high phenolic compounds has protective effects on tricyclazole induced hepatotoxicity.

Full-Text [PDF 183 kb]   (727 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2016/07/26 | Accepted: 2016/09/7

Add your comments about this article : Your username or Email:

Send email to the article author

© 2020 All Rights Reserved | Journal of Arak University of Medical Sciences

Designed & Developed by : Yektaweb