Volume 22, Issue 3 (8-2019)                   J Arak Uni Med Sci 2019, 22(3): 107-117 | Back to browse issues page

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Kamkar M, Zare S, Babaei F. The Effect of Sulpiride and Food Restriction on Depression and Anxiety Control in Adult Male Rats. J Arak Uni Med Sci. 2019; 22 (3) :107-117
URL: http://jams.arakmu.ac.ir/article-1-5556-en.html
1- Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran. , m.kamkar70@yahoo.com
2- Department of Biology, Faculty of Sciences, Urmia University, Urmia, Iran.
Abstract:   (122 Views)
Background and Aim: Food restriction (FR) affects on depression and anxiety behavior. Previous studies have pointed to the role of sulpiride in the treatment of depression and anxiety. The purpose of this study was to determine the role of dopaminergic system and food restriction on depression and anxiety.
Materials and Methods: Forty two adult male Wistar rats (180-220g) were divided into 7 groups including: control, sham, 25%, 50%, 75% FR, 75% FR with sulpiride and sulpiride(50µg/rat). The treatment period was 21 days. Day 19 surgery and cannulation was performed and Sulpiride was injected intracrebroventricularly (icv) on the 21st day. Depression and anxiety tests (Tail suspension test and Elevated Plus Maze), was taken from the rats on the 21st day. Data were analyzed by ANOVA test.
Ethical Considerations: Ethical points were observed according to the declaration of Helsinki and acts of Bioethics Committee at Urmia University (Ref No: AECVU-180-2018).
Findings: Mobility time in FR groups and sulpiride compared to control and in 75% with sulpiride compared to 75% had significant increase. immobility time in FR and sulpiride had significant decrease compared to control. Open arm entry in 75% FR had significantly decreased compared to control and in 75% FR with sulpiride had significantly increased compared to 75%. Open arm spend time in 75% FR with sulpiride had significant increase compared to 75%. Motor activity was reduced in FR groups and injection sulpiride.
Conclusion: It seems that sulpride and FR play a role in improving
semi-depression circumstances. Sulpiride also play a role in controlling the anxiety behavior induced by FR.
Full-Text [PDF 569 kb]   (61 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2018/01/8 | Accepted: 2018/12/12

References
1. Kessler RC, Bromet EJ. The epidemiology of depression across cultures. Annual review of public health. 2013; 34: 119-38.
2. Miller B. What is the connection between anxiety and fatigue? conjecture corporation 2013; 82.
3. Hammen C. Stress and depression. Annu Rev Clin Psychol. 2005; 1: 293-319.
4. Meyers S. Use of neurotransmitter precursors for treatment of depression. Alternative Medicine Review. 2000; 5(1): 64-71.
5. Dunlop BW, Nemeroff CB. The role of dopamine in the pathophysiology of depression. Archives of general psychiatry. 2007; 64(3):327-37.
6. Adriani W, Felici A, Sargolini F,Roullet P, Usiello A, Oliverio A, and et al. N-methyl-D-aspartate and dopamine receptor involvement in the modulation of locomotor activity and memory processes.Experimental Brain Research. 1998; 123: 52-59.
7. Goldstein LE, Rasmusson AM, Bunney BS, Roth RH. Role of the amygdala in the coordination of behavioral, neuroendocrine, and prefrontal cortical monoamine responses to psychological stress in the rat. J Neurosci. 1996; 16: 4787-98.
8. Masoro EJ. Overview of caloric restriction and ageing. Mechanisms of ageing and development. 2005; 126(9):913-22.
9. Haberny SL, Berman Y, Meller E, Carr KD. Chronic food restriction increases D-1 dopamine receptor agonist-induced phosphorylation of extracellular signal-regulated kinase 1/2 and cyclic AMP response element-binding protein in caudate-putamen and nucleus accumbens. Neuroscience. 2004; 125(1): 289-98.
10. Thanos PK, Michaelides M, Piyis YK, Wang GJ, Volkow ND. Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in‐vivo μPET imaging ([11C] raclopride) and in‐vitro ([3H] spiperone) autoradiography. Synapse. 2008; 62(1): 50-61.
11. Zhang Y, Liu C, Zhao Y, Zhang X, Li B, Cui R. The Effects of Calorie Restriction in Depression and Potential Mechanisms. Current neuropharmacology. 2015; 13(4): 536-42.
12. Sharpe M, Harrison PC, Gedde J. Lecture Notes: Psychiatry. Wiley-Blackwell. 2005; 64-5.
13. Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V. Displacement of [3H] γ- hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics. European journal of pharmacology. 1994; 256(2): 211-4.
14. Brown MJ, Harland D. B‐HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors. British journal of pharmacology. 1986; 87(2): 361-70
15. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates in Stereotaxic Coordinates. Elsevier; 2007.
16. Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice. NeurosciBiobehav Rev. 2005; 29(4-5): 571-625.
17. Levay EA, Govic A, Penman J, Paolini AG, Kent S. Effects of adult-onset calorie restriction on anxiety-like behavior in rats. Physiology & behavior. 2007; 92(5): 889-96.
18. Cohen ML, Shuman RT, Osborne JJ, Gesellchen PD. Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. Journal of Pharmacology and Experimental Therapeutics. 1986; 238(3): 769-72.
19. Kaplan HI, Sadock BJ, Grebb JA. Substance related disorders. Kaplan HI, Sadock BJ. Kaplan and Sadock’s synopsis of psychiatry: behavioral sciences, clinical psychiatry. 8th ed. Baltimore: Williams & Wilkins. 1998: 419-26.
20. Imperato AS, Di Chiara GA. Dopamine release and metabolism in awake rats after systemic neuroleptics as studied by trans-striatal dialysis. Journal of Neuroscience. 1985; 5(2): 297-306.
21. Davis M. The role of the amygdala in fear and anxiety. Annual review of neuroscience. 1992; 15(1): 353-75.
22. Tricklebank MD, Hutson PH, Curzon G. Involvement of dopamine in the antinociceptive response to footshock. Psychopharmacology. 1984; 82(3): 185-8.
23. Stoof JC, Kebabian JW. Two dopamine receptors: biochemistry, physiology and pharmacology. Life Sci. 1984; 35(23): 2281-96.
24. Gallagher JP, Higashi H, Nishi S. Characterization and ionic basis of GABA‐induced depolarizations recorded in vitro from cat primary afferent neurones. The Journal of physiology. 1978; 275(1): 263-82.
25. Zhang Y, Liu C, Zhao Y, Zhang X, Li B, Cui R. The Effects of Calorie Restriction in Depression and Potential Mechanisms. Current neuropharmacology. 2015; 13(4): 536-42.
26. Hussin NM, Shahar S, Teng F, Ngah W, Das SK. Efficacy of fasting and calorie restriction (FCR) on mood and depression among ageing men. The journal of nutrition, health & aging. 2013; 17(8): 674.
27. Hammack SE, Cooper MA, Lezak KR. Overlapping neurobiology of learned helplessness and conditioned defeat: implications for PTSD and mood disorders. Neuropharmacology. 2012; 62(2): 565-75
28. Govic A, Levay EA, Kent S, Paolini AG. The social behavior of male rats administered an adult-onset calorie restriction regimen. Physiology & behavior. 2009; 96(4): 581-5.
29. Manzanero S, Gelderblom M, Magnus T, Arumugam TV. Calorie restriction and stroke. Experimental & translational stroke medicine. 2011; 3(1):8.
30. Redman LM, Martin CK, Williamson DA, Ravussin E. Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes. Physiology & behavior. 2008; 94(5): 643-8.

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