Volume 28, Issue 3 (8-2025)
J Arak Uni Med Sci 2025, 28(3): 0-0 |
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Parastesh M, Yousefvand Z, Aria B, Mardaniyan Ghahfarrokh M, ahmadi J. The Effect of Endurance Training on Oxidative Stress Markers in the Brain Tissue of Rats Under Cisplatin. J Arak Uni Med Sci 2025; 28 (3)
URL: http://jams.arakmu.ac.ir/article-1-7927-en.html
URL: http://jams.arakmu.ac.ir/article-1-7927-en.html
Mohammad Parastesh1 
, Zahra Yousefvand2 , Behzad Aria3 , Majid Mardaniyan Ghahfarrokh4 , Jamileh Ahmadi5
, Zahra Yousefvand2 , Behzad Aria3 , Majid Mardaniyan Ghahfarrokh4 , Jamileh Ahmadi5
1- Associate Professor, Department of Exercise Physiology,Research Institute of Applied Studies of Sports Sciences, Faculty of Sports Sciences, Arak University, Arak, Iran
2- PhD. Department of Exercise Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran ,zahra13699631@gmail.com
3- Assistant Professor, Psychology and Educational Sciences, Department of Physical Education and Sports Science, Yazd University, Yazd, Iran
4- Assistant Professor, Department of Exercise Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran
5- MSc, Department of Exercise Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran
2- PhD. Department of Exercise Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran ,
3- Assistant Professor, Psychology and Educational Sciences, Department of Physical Education and Sports Science, Yazd University, Yazd, Iran
4- Assistant Professor, Department of Exercise Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran
5- MSc, Department of Exercise Physiology, Faculty of Sports Sciences, Arak University, Arak, Iran
Abstract: (48 Views)
Introduction: Cisplatin, a widely used chemotherapy agent, offers therapeutic benefits for cancer treatment but often leads to adverse effects on neurogenesis and oxidative stress. On the other hand, physical activity has been proposed as a potential strategy to counteract these side effects. Therefore, the aim of the present study was to investigate the effect of an endurance training period on oxidative stress markers in the brain tissue of rats induced with cisplatin.
Methods: In this study, 32 male rats with an average weight of 220 grams were divided into four groups: healthy control, cisplatin-injected control, endurance training, and cisplatin + endurance training. After 8 weeks of endurance training, the rats were dissected, and blood serum was separated to measure oxidant and antioxidant factors. Additionally, the brain was removed under sterile conditions for the examination of the desired markers. Data were analyzed using one-way ANOVA.
Results: The results showed that cisplatin significantly decreased MDA and significantly increased TAC and CAT in the cisplatin-receiving control group. On the other hand, 8 weeks of endurance training significantly decreased MDA and significantly increased TAC and CAT. Moreover, no significant change was observed in serum SOD levels. In brain tissue, MDA levels significantly increased, and TAC, CAT, and SOD levels significantly decreased in the cisplatin-receiving group. Conversely, 8 weeks of endurance training reduced MDA levels and increased TAC, CAT, and SOD levels.
Conclusions: Based on the findings of the present study, it appears that physical exercise has protective effects against cisplatin-induced oxidative stress in the brain, which may be attributed to its antioxidant capabilities
Methods: In this study, 32 male rats with an average weight of 220 grams were divided into four groups: healthy control, cisplatin-injected control, endurance training, and cisplatin + endurance training. After 8 weeks of endurance training, the rats were dissected, and blood serum was separated to measure oxidant and antioxidant factors. Additionally, the brain was removed under sterile conditions for the examination of the desired markers. Data were analyzed using one-way ANOVA.
Results: The results showed that cisplatin significantly decreased MDA and significantly increased TAC and CAT in the cisplatin-receiving control group. On the other hand, 8 weeks of endurance training significantly decreased MDA and significantly increased TAC and CAT. Moreover, no significant change was observed in serum SOD levels. In brain tissue, MDA levels significantly increased, and TAC, CAT, and SOD levels significantly decreased in the cisplatin-receiving group. Conversely, 8 weeks of endurance training reduced MDA levels and increased TAC, CAT, and SOD levels.
Conclusions: Based on the findings of the present study, it appears that physical exercise has protective effects against cisplatin-induced oxidative stress in the brain, which may be attributed to its antioxidant capabilities
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