Background: The main purpose of this study was to measure the level of lipids in ICU patients and its clinical outcome, specially the mortality rate and the relationship between level of lipids and APACHE IV score.

Materials and Methods: This descriptive and cross-sectional study was conducted on 100 ICU patients. Cholesterol level was measured on the first and second days after admission of patients. This was followed by examination of clinical outcome (e.g. mortality rate) and duration of their real and predicted stay through APACHI IV. The results were analyzed by Pearson correlation using SPSS.

Results: Mean serum of HDL, LDL, and cholesterol was lower than normal. These values for the first day were 33.16, 67.97, and 131.38 and for the second day were 23.63, 54.99, and 119.88, respectively. Mean APACH E IV score was 67.72. Result of Pearson correlation coefficient showed significant relationship (p<0.05) between APACHI IV score and cholesterol level of the first and second day, LDL level of the first and second day, HDL level of the second day. Moreover, there were significant relationships were observed between the real mortality rate and the cholesterol level of the first and second days, LDL level of the first and second days, and HDL level of the first day. There was a significant significant correlation between cholesterol level and LDL of the first and second days as well as HDL of the first day and duration of admission in ICU as predicted by APACHI IV.

Conclusion: The significant relationship between lipoprotein level of serum and APACHI IV indicates considering serum lipid beside other physiologic parameters for prediction of clinical consequences including mortality rate of ICU patients