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2- Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, Iran ,
3- Rheumatology Departments, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- Rheumatology Departments, Hormozgan University of Medical Sciences, Hormozgan, Iran
Abstract
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with broad clinical manifestations, but unclear etiology. Extensive tissue damage occurs due to the production of auto-antibody against nuclear and cytoplasmic antigens. Regarding the involvement of GADD45A gene in cell cycle control, T-cell proliferation suppression, and genome epigenetic regulation, this case-control study was done for the first time to evaluate the association of rs581000 polymorphism in 5’ near gene with the risk of SLE among patients in south of Iran.
Materials and Methods: This study was performed on 102 patients with SLE in comparison with 118 healthy controls. Genotyping of the GADD45A rs581000 polymorphism was performed using T-ARMS PCR.
Results: The T allele was significantly more frequent in the controls (0.13) than in the patients (0.01) with SLE (p<0.001). The frequency of genotypes carrying at least one C allele (CC+CG) was higher in control group (14.4%) compared to patient group (1%), and this allele showed protective effect against the risk of SLE (p<0.001, CI: 0.009-0.5, OR=0.06)
Conclusion: It seems that GADD45A rs581000 polymorphism involved in the SLE pathogenesis.
Received: 2016/07/12 | Accepted: 2016/08/21
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