Volume 21, Issue 5 (10-2018)
J Arak Uni Med Sci 2018, 21(5): 69-76 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Dalvandi M, Farahani H, Safari Rad R. Association of Lumber Disk Herniation with Serum Zinc Level. J Arak Uni Med Sci 2018; 21 (5) :69-76
URL: http://jams.arakmu.ac.ir/article-1-5740-en.html
URL: http://jams.arakmu.ac.ir/article-1-5740-en.html
1- Department of Neurosurgery. Faculty of Medicine, Arak University of Medical Science, Arak, IR, Iran.
2- Department of Biochemistry, Faculty of Medicine, Arak University of Medical Science, Arak, IR, Iran. ,farahaniheidar@yahoo.com
3- Arak Medical Science University, I.R. Iran
2- Department of Biochemistry, Faculty of Medicine, Arak University of Medical Science, Arak, IR, Iran. ,
3- Arak Medical Science University, I.R. Iran
Abstract: (3125 Views)
Background and Aim: Low Back Pain is one of the most common complains of Human societies. LDH (Lumber Disk Herniation) is one of the relatively common causes of Low Back Pain. This study aimed to assay serum zinc cofactor in patients compared to healthy group.
Materials and Methods: Sixty patients which were diagnosed as a "known case of LDH" by the specialist and based on tests were chosen by simple selection method (30 men and 30 women). Also, 57 people were chosen as a control group (29 men and 28 women). measurement was done based on single reagent direct calorimetric method using the kit made by "Ziestchem diagnostics company, Iran".
Findings: Total, 117 objects were observed in case and control groups. Serum zinc level was measured in all of them. Obtained results were analyzed by Student t-test, and ꭕ2, by using SPSS software with the confidence interval of 95 percent. Results showed that 21.7% of patients with LDH were having high physical activity and 36.7% having low physical activity.
Conclusion: There was a significant difference between the mean serum zinc levels in patients with LDH compared to control group. Decrement in serum zinc may be considered as an distruption factor in the activity of enzymes involved in proteins biosynthesis.
Materials and Methods: Sixty patients which were diagnosed as a "known case of LDH" by the specialist and based on tests were chosen by simple selection method (30 men and 30 women). Also, 57 people were chosen as a control group (29 men and 28 women). measurement was done based on single reagent direct calorimetric method using the kit made by "Ziestchem diagnostics company, Iran".
Findings: Total, 117 objects were observed in case and control groups. Serum zinc level was measured in all of them. Obtained results were analyzed by Student t-test, and ꭕ2, by using SPSS software with the confidence interval of 95 percent. Results showed that 21.7% of patients with LDH were having high physical activity and 36.7% having low physical activity.
Conclusion: There was a significant difference between the mean serum zinc levels in patients with LDH compared to control group. Decrement in serum zinc may be considered as an distruption factor in the activity of enzymes involved in proteins biosynthesis.
Type of Study: Original Atricle |
Subject:
Basic Sciences
Received: 2018/04/24 | Accepted: 2018/08/4
Received: 2018/04/24 | Accepted: 2018/08/4
References
1. Finnesson BE: Lumbar Disk Excision In. Schmidek HH, and Sweet WH(eds): Operative Neurological Techniques, Second ed, Philadelphia, Saunders Co. 2004; 1375-92.
2. Lebkowski WJ.; Ageing and degeneration of human lumber intervertebral discs. Pol MerkrLekarski. 2002; 13(75):234-7.
3. Julian Y. Extradural Caude Equine and nerve Root Compression. From Benign lesions of Lumbar spine. Neurological surgery (youmans) Philadelphia Sounders Co. 2002; 3: 2357-2377.
4. Frymoqer T.W. The adult spine principles and practice. Lumbar disk Epidemiology. New York Raven press.1999; 217-223.
5. Stephens S.E. Bell G.R. Natural history and epidemiology of lumbar disk degeneration. In Hardy R.W. Ed: Lumbar Disk disease. 2nd ed. New York, raven press. 2002; 13-15.
6. Quiner J.K Basic histology, Tanslated by: Montazeri SM, Capter 9. Arjmand publication, Tehran. 1382; 211-247.
7. Sedighi M. Haghnegahdar A. Role of vitamin D3 in Treatment of Lumbar Disc Herniation—Pain and Sensory Aspects: Study Protocol for a Randomized Controlled Trial.Trials. 2014; 15: 373.
8. Binxiu Z. Kunzheng W. Jiexiu Z. Yufeng L. Binxiu Z. Serum Calcium Concentration as an Indicator of Intervertebral disk degeneration Prognosis. Biological Trace Element Research. 2013; 154(3):333-337.
9. York LJ. Enzymes: Classification, Kinetics and control. In Text book of Biochemistry with clinical correlation. By: Devlin TM, Chapter10, fifth edition. Wiley Liss publication. 2002; 413-46.
10. Laurent Grange, Philippe Gaudin, Candice Trocmé, R Juvin .Intervertebral disk degeneration and herniation: The role of metalloproteinases and cytokines Joint Bone Spine. 2002; 68(6):547-53.
11. Takeshi Sainoh, Kazuhide Inage, Sumihisa Orita, Masao Koda, Takeo Furuya,Kazuyo Yamauchi,et al. Correlation among Inflammatory Cytokine Expression Levels, Degree of Disk Degeneration, and Predominant Clinical Symptoms in Patients with Degenerated Intervertebral Discs .Asian Spine J. 2017; 11(3): 472–477.
12. Aldenora Oliveira do Nascimento Holanda, Ana Raquel Soares de Oliveira, Kyria Jayanne Clímaco Cruz, Juliana Soares Severo, Jennifer Beatriz Silva Morais, Benedito Borges da Silva, Dilina do Nascimento Marreiro. Zinc and metalloproteinases 2 and 9: Rev Assoc Med Bras. 2017; 63(1):78-84.
13. Tohno S, Tohno Y, Minami T, Ichii M, Okazaki Y, Utsumi M, Nishiwaki F, Yamada M. Difference of mineral contents in human intervertebral disks and its age-related change. Biol Trace Elem Res. 1996; 52(2):117-24.
14. Grang L, Gaudin P, Trocme C, Phelip X, Morel F, Juvin R. Intervertebral disk degeneration and herniation: the role of metalloproteinases and cytokines. Joint Bone Spine. 2001; 68(6):547-53.
15. Kathryn T. Weber, D. Olivier Alipui, Cristina P. Sison, Ona Bloom, Shaheda Quraishi, M. Chris Overby, Mitchell Levine,and Nadeen O. Chahine Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. Arthritis Res Ther. 2016; 18: 3.
16. Zu B, Pan H, Zhang XJ, Yin ZS. Serum Levels of the Inflammatory Cytokines in Patients with Lumbar Radicular Pain Due to Disc Herniation. Asian Spine J. 2016; 10(5):843-849.
17. Coleman JE, Zinc Enzymes. Current Opinion in Chemical Biology. 1998; 2:222-234.
18. Sensi SL, Paoletti P, Bush AI, Sekler I. Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci. 2009; 10:780-191.
19. Gower-Winter SD, Levenson CW .Zinc in the central nervous system: From molecules to behavior. Biofactors. 2012; 38(3):186-93.
20. Farahani NH. Ashthiani AR, Masihi MS. Study on serum zinc and selenium levels in epileptic patients. Neurosciences. 2013; 18 (2):138-142.
21. Turgut M, Yenisey C, Akyuz O, Ozsunar Y, Erkus M, Bicakci T. Correlation of serum trace elements and melatonin levels to radiological, biochemical, and histological assessment of degeneration in patients with intervertebral disc herniation. Biol Trace Elem Res. 2006; 109(2): 123-34.
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
