Volume 3, Issue 2 (Summer 2000)
J Arak Uni Med Sci 2000, 3(2): 41-44 |
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Momeni H, Elyasi A. Study of the Subcutaneous Saline Injection Times on Blood glucose Level in NMRI Mice. J Arak Uni Med Sci 2000; 3 (2) :41-44
URL: http://jams.arakmu.ac.ir/article-1-6622-en.html
URL: http://jams.arakmu.ac.ir/article-1-6622-en.html
1- Department of Biology, Arak University of Medical Sciences, Arak, Iran.
2- Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2- Department of Physiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Abstract: (1072 Views)
In this research, factors such as animal handling, needle effect for saline injection and blood sampling from retro-orbital sinus, etc… were considered as stress-producing factors. Before percutaneous injection of the sterile saline for determination of the blood glucose base and at certain times after injection, serial blood samples were obtained from retro-orbital sinus and then the blood glucose was measured. The experiments showed that one-time injection of 10mg/kg saline caused a little hyperglycemia and two-time injection of saline at the interval of 90 minutes caused a significant hyperglycemic response in comparison to control group of the mice which received one-time injection of saline. The results of the studies indicate that stress-producing factors cause stimulation of sympathoadrenal and hypothalamus – hypophisis- adrenal axel and as a result it causes an increase in plasma catecolamines and cortisole and finally by different mechanisms causes hyperglycemia.
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