Volume 14, Issue 2 (5-2011)
J Arak Uni Med Sci 2011, 14(2): 81-88 |
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Moshiri E, Norozi A, Pazoki S, Gazerani N, Choghayi M. The effect of low dose Ketamine on postoperative pain after spinal anaesthesia in cesarean section. J Arak Uni Med Sci 2011; 14 (2) :81-88
URL: http://jams.arakmu.ac.ir/article-1-729-en.html
URL: http://jams.arakmu.ac.ir/article-1-729-en.html
1- , Moshiri_E@yahoo.com
Abstract: (21718 Views)
Background: Postoperative pain brings about undesirable effects such as medical complications, increased healthcare costs, and the need for opioids administration. The aim of this study was to determine the effect of low dose (0.15 mg/kg) ketamine in comparison with the placebo on postoperative pain and analgesics consumption after cesarean section.
Materials and Methods: In a randomized clinical trial, 120 women undergoing elective cesarean section were randomly divided into case and control groups. Ketamine (0.15 mgkg-1) or an equal volume of normal saline were administered intravenously immediately after initiating spinal anesthesia to the case and control groups, respectively. The anesthesia and surgery techniques were the same for both groups. Data were analyzed using SPSS version 11.
Results: Means of age in the case and control groups were 28.85±4.81 and 28.87 ±5.62 years, respectively. Analgesics consumption, pain scores, homodynamic signs, drowsiness of the mothers, and the neonates’ Apgar scores after cesarean section were similar in both groups and no significant differences were found between them (P>0.05). The mean of postoperative arterial pressure in the early hours in the ketamine group showed a significant decrease compared to the placebo group (P>0.03). The means of the first time of request for analgesics after surgery in the ketamine and placebo groups were 99.75±68.88 and 96.1±52.59 minutes, respectively (P>0.05).
Conclusion: It seems that the administration of 0.15 mg/kg dose of ketamine (0.15mg/kg) does not have a significant impact on decreasing the postoperative pain in cesarean section. Therefore, in order to obtain the desirable analgesic effects of this drug, further studies should be conducted with greater doses of this drug and its use in combination with other opioids.
Subject:
Anesthesia
Received: 2010/05/19
Received: 2010/05/19
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