Volume 19, Issue 9 (12-2016)                   J Arak Uni Med Sci 2016, 19(9): 107-116 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Louei Monfared A, Hamoon Navard S. The Effects of Methylphenidate Administration on the Histological Alterations of the Lymphatic System in the Mice. J Arak Uni Med Sci 2016; 19 (9) :107-116
URL: http://jams.arakmu.ac.ir/article-1-4495-en.html
1- Department of Anatomy and Histology, University of Ilam, Ilam, Iran , alm722@gmail.com
2- Islamic Azad University, Hamedan
Abstract:   (4278 Views)

Abstract

Background: The lymphatic system as a key component in the organism's body can be affected by used drugs. Methylphenidate or Ritalin is widely used for treatment of behavioral disorders in children and some depressed people. This study carried out to examine the immunotoxic effects of Ritalin.

Materials and Methods: A total of 16 healthy adult female mice were selected and randomly divided into a control and three experimental groups. The experimental groups received Ritalin as 0.5,5 and 50 mg/kg body weight and control groups received distillated water by gavage method for 21 consecutive days. At the end of experiment, the structure and function of the lymphoid organs were evaluated. Results were analyzed by ANOVA and Duncan’s test (p<0.05).

Results: Significant alterations including a reduction in the size and number of lymphoid follicles, increasing in the megakaryocytes numbers as well as spleen capsular thickens were seen following Ritalin administration.  The atrophy of the lymph nodes together with significant reduction in the number and size of lymph follicles but an increasing in the parenchyma hyperemia were seen. Also lymphocyte numbers increased while the monocytes numbers decreased (p<0.05).

Conclusion: The consumption of Ritalin could be exerted detrimental effects on the lymphoid organs in the mouse model.

Full-Text [PDF 1261 kb]   (2979 Downloads)    
Type of Study: Original Atricle | Subject: Basic Sciences
Received: 2016/06/20 | Accepted: 2016/08/13

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Arak University of Medical Sciences

Designed & Developed by : Yektaweb